Curriculum Vitae

Nikolas Ploutarch Benetis

Born on September 14, 1950 in Athens, Greece

Citizenship
Greek, Swedish

Professional address
Institute of Biology, Medicinal Chemistry and Biotechnology
Laboratory of Molecular Analysis, National Hellenic Research Foundation, NHRF
Vas. Konstantin str. 48, Athens GR-116 35, Greece
Tel: +30-2-10-727 38 69, Fax: +30-2-10-727 38 31, elmail: niben@eie.gr

Education

  • Graduate of Athens University. Natural Sciences and Geography December 16, 1975
  • Graduate of Stockholm University. Chemistry and Mathematics May 15, 1981
  • Postgraduate Courses. Physical Chemistry, Physics and Mathematics April 4 1983
  • PhD, Doctor of Physical Chemistry. University of Stockholm June 5, 1984
  • Postdoctoral Studies. University of Cornell, Ithaca, New York, with Professor Jack H. Freed, July1985-July 1986
  • Docent and Associate Professor Chemical Physics, Linköping University October 5, 1988

Languages

Greek, Swedish, English; very well, Spanish, French; not so well. Learning currently Japanese.

Pedagogical Qualification
Assistant

  • General Chemistry. (Undergraduate education course, Stockholm University)
  • Physical Chemistry. (Undergraduate education course, Stockholm University)
  • Physical Chemistry. (Advanced- and prograduate education course, Stockholm University)
  • Quantum-Mechanics/Spectroscopy. (Prograduate education course, Stockholm University)
  • Statistical Thermodynamics. (Prograduate education course, Stockholm University)
  • Planning and introduction of new Course-Laboratory Exercise with tittle Relaxation Kinetics, in the C-course for Physical Chemistry at the University of Stockholm.

Lecturer

  • Quantum-Mechanics/Spectroscopy. (Prograduate education course, Stockholm University)
  • Magnetic Resonance Spectroscopy. (Partially. Graduate education course at Linköping University)
  • Magnetic Resonance Spectroscopy for Medical Doctors. (Partially. RIL Regional Hospital in Linköping)
  • Quantum Dynamics in Simple Spin Systems. Graduate course given in both Swedish and English version given every second year, latest 1997. Compendium with relevant material has been worked out.

Supervisor

(I) Ulf Nordh, ESEEM simulations
Diploma Work. ''Theoretical ESR Lineshapes of an Exchanging Three-site System Calculated Using the Liouville Formalism. Comparison with the Organic Radical CH3COOD-.''
Linköping University 1989.
Publications. Three published articles see publication list.
   
(II) Maria Engström, Theory of realistic pulses. Quantum Chemistry computations of NO gas properties in Zeolites.
Diploma Work. ''Theoretical treatment of pulses in magnetic resonance.''
LiU-IFM-Fysik-Ex415, September 1995
Publications. Partial results of this student are included in two publications with acknowledgment to her name.
   
(III) Anders Sornes, Simulations of Spin and Motional Dynamics. Thermodynamic Limits of Motion for Small Symmetric Rotors, Studied by Solid State EPR.
He became a PhD in Physics summer 1998 in Oslo University.
PhD Thesis. ''Numerical Methods in Magnetic Resonance. Analysis and Simulations in Quest of Structural and Dynamical Properties of Free Radicals in Solids.''
Publications. Six published articles see publication list.

Currently

(IV) Fotakis Charalambos and
(V) Christodouleas Dionisios, Physical Chemistry in The Capodestrian University of Athens
(VI) Gili Argiro, Polytechnic School of Athens:
  Broadline simulation of static CP 31P NMR and applications in modeling phospholipid bilayer:drug interaction. DPPC / water bilayers and inclusions of antihypertensive pepdidomimetics are under study.
This project has started within 2004 and at least two articles are under publication and several conference presentation.
   
(VII) Agnes Kapou Quantitative (3D) Structure Activity Relationship (QSAR) investigations concerning the Antileishmanial activity of several homologue etherolipids.
Also recently started 2004 project under development, with one publication on the way.

PROFESSIONAL OCCUPATION

Stockholm University: Assistant and Research Assistant, from November 30, 1979 until December 31, 1984 [Read more ]
Linköping University: Research Specialist, Research Assistant, Lecturer of Higher Education, and University Lecturer, from May 1, 1987 until unspecified date
Docent and Associate Professor: From October 5, 1988 until unspecified date,
Chemical Physics Laboratory, Department of Physics and Measurement Technology, Linköping University, Sweden
Research associate: From July 1, 2003,
Institute of Biology, Medicinal Chemistry and Biotechnology, Division of Organic & Medicinal Chemistry (OMC)
Laboratory of Molecular Analysis, National Hellenic Research Foundation, NHRF

OUTLINE OF RECENT INTERNATIONAL RESEARCH COOPERATION
1) Stipend for living and research costs in Hiroshima, Japan for a 6 months period, August 15, 1999 to February 11, 2000, obtained from Kungliga Vetenskapaskademien KVA (The Royal Swedish Academy of Sciences) and JSPS (The Japanese Society for the Promotion in Science.)
Research program: Quantum effects of the interaction of rotation with the spins in small methyl-type radicals isolated in solid inert gas matrices at low temperature, as they appear in the EPR spectra.
Host Institute leader: Prof. Masaru SHIOTANI, Faculty of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527, JAPAN, Tel/Fax: +81-(0)824-24-7736
Email: mshiota@ipc.hiroshima-u.ac.jp

2) From March 29 to September 29, 2000 visiting professor in the laboratory of the Physical Chemistry of the Weizmann laboratory in Israel. The project had the aim to characterize theoretically the ESEEM and HYSCORE spectra in paramagnetic Kramers' higher multiplets (S >1/2) in disordered solids, and perform simple experimental verification of the theory.
Group leader was Professor Daniella Goldfarb, who was also the director of the Chemistry Institute. Her full address is: Department of Chemical Physics, the Weizmann Institute of Science Rehovot 76100, Israel Phone: 972-8-9342016, FAX: 972-8-9344123, Email: daniella.goldfarb@weizmann.ac.il

3) From January 2001 a cooperation with Professor D. Galaris from University of Ioannina with partial financiering from the Department of the Pathology of the Peripheral Hospital of the town of Linköping, Sweden. Responsible Swedish person was prof. Ulf Brunk ulf.brunk@pat.liu.se
Full address of prof. D. Galaris is: Department of Biological Chemistry, School of Medicine of the University of Ioannina, 451 10 Ioannina. Tel: +30-651-97 562, FAX: +30-651-97 868, Email dgalaris@cc.uoi.gr
The central question of that project was the determination of the role of the lyssosomes in the damage of the DNA of living cells exposed to controlled amounts of hydrogen peroxide Ç2Ï2 during prolonged time periods
Another aim was to decide by bibliographic search about the possibility to improve the oxidative stress research which was performed by biochemistry methods by the laboratory of Prof. Galaris by utilization of EPR. The title of the produced document was: ''EPR investigation of Oxidative Stress. The objective and aims.''
The cooperation with professor Galaris demonstrated that the study of the characteristics, the properties, and the mechanisms of action of at least one important category of antioxidants with the EPR (Electron Paramagnetic Resonance) methods, was ideal. Such antioxidants are certain iron-chelating and generally metal-chelating substances of relatively small molecular weight. This project is continuing in my current employment in the National Hellenic Research Foundation, see last entry.

4) After invitation of Prof. Marina Brustolon of Physical Chemistry in Padova University, Italy I visited the University of Padova for one week, between February 3 and February 10, 2002, where I gave a lecture about my recent developments of ESEEM and HYSCORE simulations for higher electronic multiplets. The title of the lecture was: ''ESEEM and HYSCORE spectra of higher Kramer's multiplets (S > 1/2) in orientationally disordered systems.'' In addition I started cooperation with two different experimental groups as well as one theorist. This cooperation concerns the simulation of the experimental pulsed EPR spectra of one ATP-ase and one dismutase with the simulation program of 2D-HYSCORE that I did in Israel.
The full address of prof. Brustolon is: Prof. Marina Brustolon, Dipartimento di Chimica Fisica. Via Loredan 2, I-351 31 Padova, Italy. Tel. +049-82 75 680, Fax + 049-82 75 135, e-mail M.Brustolon@chfi.unipd.it

5) From the beginning of July until September 2002, after invitation of Prof. Sergei Dzuba, I visited the Institute of Chemical Kinetics and Combustion in Novosibirsk for three months and worked together with him and his collaborators. In that Institute have their basis many theorists and experimentalists that are pioneers for their contribution in the early stages of the developments of the field of pulsed EPR.
One of the aims with my cooperation was the theoretical interpretation of experimentally obtained modulations of the ESE (Electron Spin Echo) signals of paramagnetic systems that eventually exhibited tunneling effect in some motional degree of freedom. In spite of the semiquantitative explanations of the group, the generation of the modulations was still ambiguous.
In addition to that, prof. Dzuba sent me in advance a preprint of his most recent work which was devoted in the study of the effects of small amplitude librations in the pulse detected CW EPR spectra of several nitroxides. This method was used repeatedly by the group for the study of frozen solutions of biological material in the form of glass for temperatures around the liquid nitrogen temperature, where they were studied. The review of these articles is included in a chapter which I wrote about dynamics in solids and which was published 2003 by Kluwer, see list of publications.
Full address of Prof. Sergei A. Dzuba is: Institute of Chemical Kinetics and Combustion, Ul. Institutskaya-3, 630090 Novosibirsk, Russian Federation, tel +7 3832 331276, fax +7 3832 342350, e-mail dzuba@ns.kinetics.nsc.ru

6) Between March 6 and June 6 2003, I was visiting Prof. Sergei Dikanov at the Illinois EPR Research Center in the USA, after his invitation to cooperate. Professor Dikanov is one of the pioneer experts of theoretical and experimental pulsed EPR, and one of the most active researchers in applying HYSCORE (HYperfine Sublevel Correlation Spectroscopy), the 2D-variation of pulsed EPR, on paramagnetic biological systems. He has been working for many years now with the systematic study of proteins containing the Rieske center, which includes iron-sulfur clusters such as [2Fe-2S]. The structural determination of Fe-S clusters in connection to the redox potential of the related enzymes is one of the aims of this research. It involves the treatment and the evaluation of the experimental data that have been collected by Prof. Dikanov. Our cooperation will be based on simulations with the software which will be an improved version of the software which I developed in cooperation with prof. Daniella Goldfarb from The Weitzman institute, see above point 2. This software is appropriate for the simulation of pulsed EPR spectra in one and two dimensions and was presented in the conference Voevodsky in Russia. (VI Voevodsky Conference. Physics and Chemisty of elementary chemical processes, July 21-25, 2002, Novosibirsk Russia). In particular the spectra of the complexes of the first and the second transition series of the metals in the periodic table, containing ions of type Kramers with half integer electron spin. Presently I continue to improve this simulation program in cooperation with my ex director Anders Lund from the University of Linköping In Sweden.
However, another project was seen to be more fruitful during my period in Illinois. Using a graphical / analytical method, the characteristics of the ESEEM spectra of N-14 in doublets was possible to be presented in the form of simplified diagrams. The biological exploitation of this method is expected to be high due to the large number of the systems where imidazoline is functioning as a ligand of metal-ion centra.
Full address of Prof. S. Dikanov is: Illinois EPR Research Center Urbana/Champaign, IL 618 01, USA. Email dikanov@ux1.cso.uiuc.edu

(Additional details of the work performed during the above six instances are available in separate document)

7) I am presently trough an ENTER project employed in the laboratory of Dr. Thomas Mavromoustakos, in the National Hellenic Research Foundation in Greece, working as scientific research associate. Dr. Mavromoustakos works with the investigation of the relation between structure and the biological activity of certain pharmaceutical molecules by utilization of experimental NMR and numerical methods, as well as molecular modeling with help of quantum chemistry computations and molecular graphics. My contribution here is the theoretical NMR, both with respect of teaching and research. So, except for the above mentioned students who I mention as supervisor, I have instructed partially the student Panagiotis Zoumboulakis with his doctoral thesis defended in the year 2004 in his chapter about the simulations and fitting of high resolution NMR spectra. My contribution was to help him with explanation and derivation of the mathematical treatment. Concerning research, I have taken care of the theoretical interpretation of the experimental NMR spectra, in particular solid state CP 31P NMR, and with this the optimum exploitation of the experimental results of our laboratory. This method is applied currently in the investigation of the bilayer:drug interaction of certain peptides and antihypertensive peptidomimetics.
We intend also to combine EPR methods, which are my main field of research the latest 10 years, in addition to the other methods of the laboratory, for the investigation of the properties of pharmaceutical molecules.
We also currently apply the QSAR methods CoMFA and CoMSIA for the improvement of antileishmanial activity of certain flexible ether phospholipids, and the investigation of the antioxidant activity of flavonoids.
The full address of prof. Thomas Mavromoustakos is: Institute of Biology, Medicinal Chemistry and Biotechnology, Division of Organic & Medicinal Chemistry (OMC), Laboratory of Molecular Analysis, National Hellenic Research Foundation, EIE, Vas. Constantine str. 48, Athens GR-116 35, Greece
Tel: +30-2-10-727 38 69, Fax: +30-2-10-727 38 31, Email tmavro@eie.gr

INDUSTRIAL EXPERIENCE

Development of NMR-Imaging Contrast Substance for the Company NYCOMED at IDEON in Malmö, Sweden under a period of six months, 1990.

SCIENTIFIC TOPICS

  • Theory of the nuclear spin-spin and spin-lattice relaxation for bulky paramagnetic metal complexes in viscous solutions, that is, under conditions of slow motion for the electron spin
  • Simulation of CW-EPR (Continuous-Wave Electron Paramagnetic Resonance) lineshapes of anisotropic systems under chemical reorganization (exchange). In particular study of the intramolecular motion of small cyclic hydrocarbons isolated in inert matrices, at liquid-He and liquid-Nitrogen temperatures in the solid state
  • Theoretical pulsed EPR and applications
    á) Simulations of ESEEM (Electron Spin Echo Envelope Modulation) and HYSCORE (Hyperfine Sublevel Correlation Spectroscopy) by direct diagonalization of the high-field spin Hamiltonian.
    â) Simulation of ESEEM (Electron Spin Echo Envelope Modulation) patterns of non-secular paramagnetic systems
    ã) Graphical and analytical diagonalisation approach of the sublevel spin Hamiltonians of N-14 nuclei with full quadrupole and application to simplified determination of the ESEEM modulation frequencies in electronic doublets.
  • Spin-rotational coupling in ''extremely light'' and ''highly symmetric'' paramagnetic methyl-type rotors, on, and between the diffusional and the inertial thermodynamic limits. Quantum effects found on the EPR-lineshapes and ESEEM
  • Study of association forms and dynamics of small gaseous molecules such as nitrogen monoxide NO, confined in the Zeolite cavities, using EPR and numerical methods
  • Simulation of pulsed EPR methods such as one- and two-dimensional ESEEM and HYSCORE for higher Kramers' multiplets. Applications in Mn(II) complexes.

Currently: Applications of theoretical and experimental NMR in combination to quantum chemistry and empirical computational methods on rational pharmacological design.
So far, the effects of Glu or beta-Ala-Tyr inclusion in DPPC / water dispersions were investigated by using P-31 CP NMR broadline simulations in static samples. On the way to publish more systematic results with the help of a fitting version of the P-31 NMR simulation program: The effects of the commercial antihypertensives Losartan, Candesartan and their metabolites on the conformation of model membranes.

PUBLICATIONS

43 research articles, published in international scientific journals until March 2005.
The list of these articles is also attached in this CV and includes also, besides the articles, a selected collection of 10 recent / interesting proceedings in Greek and international conferences,
1 PhD dissertation, with the title, ''Nuclear-Spin Relaxation in Paramagnetic Metal Complexes and the Slow-Motion Problem for the Electron Spin'',
1 tutorial compendium with title ''Quantum-Dynamics in Simple Spin Systems''.

REFERENCES

The above articles have been referred by other investigators in a total of 570 times in totally 302 publications until the April 2004 (460 references and 270 publications when auto-references were eliminated.)

PERSONS OF REFERENCE (Ex Cooperators and directors)

Please contact also with any of the above mentioned persons with whom I cooperated during different periods and furthermore with the following two. The first of them was my latest director for me in Sweden and the second one was our scientific cooperator during my time in the University in Linköping in Sweden.
The addresses, the telephones, the faxes, and the e-mails of these persons have been included in the above text.

1) Professor Anders Lund,
Tel 46-13-282665, 070-3573577; e-Mail ald@ifm.liu.se
Fax 46-13-137568
Department of Physics and Measurement Technology
Linköping University, SWEDEN
 
2) Professor Einar Sagstuen,
Tel: + (47) 228 55653; e-mail: einar.sagstuen@fys.uio.no
Fax: + (47) 228 55671
Department of Physics, University of Oslo,
P.O. Box 1048 Blindern, N-0316 Oslo, NORWAY.

PUBLICATIONS

Articles

  1. L. Nordenskiöld, J. Kowalewski and N. Benetis.
    Kinetics of Ligand Exchange and 13C Nuclear Spin Relaxation in Paramagnetic Complexes of Ni(dpm)2.
    J. Phys. Chem. 84(26) (1980) 3646-3652
  2. N. Benetis, K. Holmen, J. Kowalewski, L. Nordenskiöld and O. Wahlberg.
    Investigation of Nickel(II)-Ascorbic Acid Complex Formation in Aqueous Solution Using Potentiometric Measurements, Optical Spectroscopy and 13C NMR Spectroscopy.
    Acta Chem. Scand. A35 (1981) 513-520
  3. L. Nordenskiöld, J. Kowalewski and N. Benetis.
    Interactions of L-Ascorbic Acid with Transition Metal Ions in Water Solution. A C-13 NMR Spin-Lattice Relaxation Study.
    Inorg. Chim. Acta L21 (1981) 56
  4. N. Benetis, J. Kowalewski, L. Nordenskiöld, H. Wennerström and P.O. Westlund.
    Nuclear Spin Relaxation in Paramagnetic Systems. The Slow Motion Problem for Electron Spin Relaxation.
    Mol. Phys. 48:2 (1983) 329-346
  5. N. Benetis, J. Kowalewski, L. Nordenskiöld, H. Wennerström and P.O. Westlund.
    Dipole-Dipole Nuclear Spin Relaxation. A Cross-Correlation Correction to the Solomon Bloembergen Equation for T2.
    Mol. Phys. 50:3 (1983) 515-530
  6. N. Benetis, J. Kowalewski, L. Nordenskiöld, H. Wennerström and P.O. Westlund.
    Nuclear Spin Relaxation in Paramagnetic Systems (S=1) in the Slow-Motion Regime for the Electron Spin. II. The Dipolar T2 and the Role of Scalar Interaction.
    J. Magn. Res. 58 (1984) 261-281
  7. N. Benetis, J. Kowalewski, L. Nordenskiöld and U. Edlund.
    Nuclear Spin Relaxation in a Paramagnetic Nickel(II) Complex. An Experimental Test of New Theoretical Models.
    J. Magn. Res. 58 (1984) 282-293
  8. P.O. Westlund, H. Wennerström, L. Nordenskiöld, J. Kowalewski and N. Benetis.
    Nuclear Spin-Lattice and Spin-Spin Relaxation in Paramagnetic Systems in the Slow-Motion for the Electron Spin. III. Dipole-Dipole and Scalar Spin-Spin Interaction for S=3/2 and S=5/2.
    J. Magn. Res. 59 (1984) 91-109
  9. N. Benetis and J. Kowalewski.
    Nuclear Spin Relaxation in Paramagnetic Systems (S=1) in the Slow Motion Regime for the Electron Spin. IV. Motional Anisotropy and Non-Coinciding Dipole-Dipole and Zero-Field Splitting Tensors.
    J. Magn. Res. 65 (1985) 13-33
  10. J. Kowalewski, L. Nordenskiöld, N. Benetis and P.O. Westlund.
    Theory of Nuclear Spin Relaxation in Paramagnetic Systems in Solution.
    Progr. NMR Spectr. 17 (1985) 141-185
  11. N.P. Benetis.
    Spin-Lattice Relaxation of Ligand Nuclei in Slowly Reorienting Paramagnetic Complexes in the Electronic Doublet Spin State (S=1/2). A Theoretical Approach of Strongly Coupled Two-Spin Systems.
    J. Magn. Res. 68 (1986) 469-489
  12. P. O. Westlund, N. Benetis and H. Wennerström.
    Paramagnetic Proton Nuclear Magnetic Relaxation in the Ni2+- hexaquo Complex. A Theoretical Study.
    Mol. Phys. 61:1 (1987) 177-194
  13. N.P. Benetis, D.J. Schneider and J.H. Freed.
    Theory for Dynamic Lineshapes of Strongly Correlated Two-Spin Systems.
    J. Magn. Res. 85 (1988) 275-293
  14. N.P. Benetis and J. Westerling.
    Nonperturbative Simulation of Two-Pulse Electron Spin-Echo Envelope Modulation Spectra. Comparison with Experimental Single-Crystal Spectra.
    J. Magn. Res. 86 (1990) 97-109
  15. N.P. Benetis, M. Lindgren, H-S. Lee and A. Lund.
    Intramolecular Dynamics in Small Radicals with Anisotropic Magnetic Interactions. ESR Lineshapes of ·CH2-COO- Trapped in Irradiated ZnAc Single Crystal.
    Appl. Magn. Res. 1 (1990) 267-281
  16. N.P. Benetis, L. Sjöqvist, A. Lund and J. Maruani.
    Theoretical Comparison and Experimental Test of the Secular and Nonperturbative Approaches of the ESR Lineshapes of Randomly Oriented, Anisotropic Systems Undergoing Internal Motion.
    J. Magn. Res. 95:3 (1991) 523-535
  17. L. Sjöqvist, N.P. Benetis, A. Lund and J. Maruani.
    Intramolecular Dynamics in the C4H8NH Radical Cation. An Application of the Anisotropic Exchange Theory for Powder ESR Lineshapes.
    Chem. Phys. 156 (1991) 457-464
  18. R. Erickson, U. Nord, N.P. Benetis and A. Lund.
    ESR Lineshapes and Methyl Rotation in the Acetic Acid Anion Radical.
    Chem. Phys. 168:1 (1992) 91-98
  19. O.N. Antzutkin, N.P. Benetis, M. Lindgren and A. Lund.
    Molecular Motion of the Morpholine-1-yl Radical in CF2ClCFCl2 as Studied by ESR. Use of Residual Anisotropy of Powder Spectra to Extract Dynamics.
    Chem. Phys. 169:2 (1993) 195-205
  20. M. Lindgren, R. Erickson, N.P. Benetis and O.N. Antzutkin.
    The THF-d8 Radical Cation in CF3CCl3 and CFCl3. An EPR and ENDOR Study.
    J. Chem. Soc. Perkin Trans. 2, 11 (1993) 2009-2014
  21. N.P. Benetis, A.S. Mahgoub, A. Lund and U.E. Nordh.
    Rotation of Deuterated Methylene Groups in the Diffusional Regime. Isotope Effect of Anisotropic alfa-Deuterons on ESR Lineshapes of ·CD2-COO- Radical in Irradiated ZnAC Dihydrate Single Crystal.
    Chem. Phys. Lett. 218 (1994) 551-556
  22. M. Lindgren, N.P. Benetis, M. Matsumoto and M. Shiotani.
    A Study of the Dynamic Equilibrium Between Symmetrical and Distorted 1,2,3- trimethyl- cyclohexane Radical Cations.
    Appl. Magn. Res. 9:1 (1995) 45-59
  23. U.E. Nordh and N.P. Benetis.
    Extension of the Accessible Dynamical Range of Reorganization in ESEEM Simulations of Single Crystals.
    Chem. Phys. Lett. 244:3-4 (1995) 321-330
  24. N.P. Benetis and U.E. Nordh.
    Non-Secular Simulation of Frequency Domain Two-Pulse Powder ESEEM Signals in Multinuclear Systems.
    Chem. Phys. 200:1-2 (1995) 107-118
  25. R.R. Rakhimov, N.P. Benetis, A. Lund, J.S. Hwang, A.I. Prokof'ev and Y.S. Lebedev.
    Intramolecular and Reorientation Dynamics of bis (triphenyl phosphine)-3,6-di-tert. butyl-4,5-dimethoxy-o-Semiquinone Complex of Copper(I) in Viscous Media.
    Chem. Phys. Lett. 255:1-3 (1996) 156-1622
  26. N.A. Salih, O.I. Eid, N.P. Benetis, M. Lindgren, A. Lund and E. Sagstuen.
    Reversible Conformation Change of Free Radicals in X-Irradiated Glutarimide Single Crystals Studied by ENDOR.
    Chem. Phys. 212 (1996) 409-419
  27. A.R. Sornes and N.P. Benetis.
    The Methyl-Rotor Electron-Spin Dynamics in the Smoluchowsky Drift-Diffusional Model Framework.
    J. Magn. Res. 125:1 (1997) 52-64
  28. R. Erickson, N.P. Benetis, A. Lund and M. Lindgren.
    Radical Cation of Naphthalene on H-ZSM-5 Zeolite and in CFCl3 Matrix. A Theoretical and Experimental EPR, ENDOR and ESEEM Study.
    J. Phys. Chem. A 101:13 (1997) 2390-2396
  29. A.R. Sornes, N.P. Benetis And R. Erickson, A.S. Mahgoub, L. Eberson and A. Lund.
    Effect of Isotopic Substitution on the Electron Spin Dynamics of the CH3C·(COOH)2 Radical in X-Irradiated Methyl Malonic Acid Powder: Intrinsic Potentials and Activation Energies.
    J. Phys. Chem. A 101:48 (1997) 8987-8994
  30. A.R. Sornes and N.P. Benetis.
    The EPR Spectrum of the General >C·-CX3 Quantum Rotor.
    Chem. Phys. 226:1-2 (1998) 151-170
  31. A.R. Sornes and N.P. Benetis.
    Theory of ESEEM in Isotropic Tunneling Methyl Rotor Systems.
    Chem. Phys. Lett. 287 (1998) 590-596
  32. Tomoya Yamada, Kenji Komaguchi, Masaru Shiotani, Nikolas P. Benetis and Anders R. Sornes.
    High Resolution EPR and Quantum Effects on CH3, CH2D, CHD2 and CD3 Radicals under Argon-matrix Isolation Conditions.
    J. Phys. Chem. A 103:25 (1999) 4823-4829
  33. Ramakant M. Kadam, Yoshiteru Itagaki, Nikolas P. Benetis, Anders Lund, Roland Erickson, Martina Huber and Wojciech Hilczer.
    An EPR, ENDOR and ESEEM Study of the Benzene Radical Cation in CFCl3 Matrix: Isotropic Substitution Effects on Structure and Dynamics.
    Phys. Chem. Chem. Phys. 1 (1999) 4967-4974
  34. Yoshiteru Itagaki, Nikolas P. Benetis, Ramakant M. Kadam and Anders Lund.
    Structure of Dimeric Radical Cations of Benzene and Toluene in Halocarbon Matrices: ESR, ENDOR and MO Study.
    Phys. Chem. Chem. Phys. 2 (2000) 2683-2689
  35. H. Yahiro, A. Lund, N. P. Benetis and M. Shiotani.
    An EPR Study on Nitrogen Monoxide Adsorbed on Sodium Ion-Exchanged A-type Zeolite.
    Chemistry Letters, Chemical Society of Japan, 2000, 736-737,
  36. Nikolas P. Benetis and Anders R. Sornes.
    Automatic Spin-Hamiltonian Diagonalization for Electronic Doublet Coupled to Anisotropic Nuclear Spins Applied in One- and Two-Dimensional ESE Simulations
    Concepts in Magnetic Resonance 12:6 (2000) 410-433
  37. Hidenori Yahiro, Anders Lund, Roland Aasa, Nikolas P. Benetis, and Masaru Shiotani.
    Association Forms of NO in Sodium Ion-exchanged A-type Zeolite: Temperature-dependent Q-band EPR spectra.
    J. Phys. Chem. A. 104:34 (2000) 7950-7956
  38. Nikolas P. Benetis, Paresh Dave, and Daniella Goldfarb.
    Characteristics of ESEEM and HYSCORE Spectra of Higher Electron-Spin Multiplets (S >1/2) in Orientationally Disordered Systems
    J. Magn. Res. 158 (2002) 126-142
  39. Nikolas P. Benetis.
    Dynamical Effects in CW and Pulsed EPR. Chap. 3 in ''EPR of Free Radicals in Solids. Part I Trends in methods'' edt. by Anders Lund and Masaru Shiotani, Kluwer, 2003
  40. T. Mavromoustakos, M. Zervou, P. Zoumpoulakis, I. Kyrikou, N.P. Benetis, L. Polevaya, P. Roumelioti, N. Giatas, A. Zoga, P. Moutevelis-Minakakis, A. Kolocouris, D. Vlahakos, S. Golic Grdadolnik, and J. Matsoukas.
    Conformation and Bioactivity. Design and Discovery of Novel Antihypertensive Drugs.
    Current Topics in Medicinal Chemistry 4 (2004) 385-401
  41. T. Mavromoustakos, A. Kapou, N.P. Benetis, and M. Zervou.
    Conformational Analysis Using 2D NMR Spectroscopy Coupled with Computational Analysis as an Aid in the Alignment Procedure of 3D-QSAR studies.
    Drug Design Reviews-Online 483-486 (2004)
  42. N.P. Benetis, I. Kyrikou, T. Mavromoustakos, and M. Zervou.
    Static 31P CP NMR Multilamellar Bilayer Broadlines in the Absence and Presence of
    the Bioactive Dipeptide beta-Ala-Tyr or Glu.

    Chem. Phys. 314:1-3 (2005) 57-72
  43. Nikolas-P. Benetis and Sergei A. Dikanov
    Influence of the anisotropic hyperfine interaction on the 14N ENDOR and the ESEEM orientation-disordered spectra.
    Journal Magnetic Resonance March 2005 in press

    Selected Proceedings
  44. J. Kowalewski, N. Benetis, T. Larsson, P.O. Westlund and H. Wennerström.
    Nuclear Spin Relaxation in Paramagnetic Ni(II) Complexes.
    Proc. Int. Symp. on Adv. Magn. Res. Techniques in Systems of High Molecular Complexities, PBB Vol.2 197-211, Edts. Neri Noccolai and Gianni Valensin , Birkhausen, Boston 1986
  45. H. Yahiro, Haitao Li, N.P. Benetis, M. Lindgren, A. Lund, M. Nagata and M. Shiotani.
    ESR Study of Nitrogen Oxides adsorbed on Zeolites.
    Proceedings of International Symposium on Zeolites and Microcroporous Crystals, Tokyo Japan1997
  46. Masaru Shiotani, Tomoya Yamada, Kenji Komaguchi, Nikolas P. Benetis, Anders Lund and Anders R. Sornes.
    CH3 and CD3 Radicals Isolated in Argon: High Resolution ESR Spectra and Analysis by Three-Dimensional Quantum Rotor Model.
    The Meeting on Tunneling Reactions and Low Temperature Chemistry, JAERI- Conf. 98-014, p. 58-63, 1998
  47. Ramakant M. Kadam, Yoshiteru Itagaki, Nikolas P. Benetis, Anders Lund, Roland Erickson, Martina Huber and Wojciech Hilczer.
    An EPR, ENDOR and ESEEM Study of the Benzene Radical Cation in CFCl3 Matrix: Isotropic Substitution Effects on Structure and Dynamics.
    3rd International Conference on Low Temperature Chemistry July 26-30, Nagoya 1999
  48. Masaru Shiotani, Tomoya Yamada, Kenji Komaguchi and Nikolas P. Benetis.
    Quantum Dynamics of Organic Radicals in Matrix.
    3rd International Conference on Low Temperature Chemistry July 26-30, Nagoya 1999
  49. Hidenori Yahiro, Nikolas P. Benetis, Anders Lund and Masaru Shiotani.
    EPR Studies on Nitrogen Monoxide in Zeolites.
    13th International Zeolite Conference. July 8-13, 2001, Montpellier, France
  50. Nikolas Ploutarch Benetis, Daniella Goldfarb, and Paresh C. Dave.
    Characteristics of ESEEM and HYSCORE Spectra of Higher Kramers Spin Multiplets (S >1/2) in Orientationally Disordered Systems.
    VI Voevodsky Conference. Physics and Chemistry of elementary Chemical processes, July 21-25, 2002, Novosibirsk Russia
  51. Pierre Dorlet, Marilena DiValentin, Nikolas P. Benetis, Donatella Carbonera, Marina Brustolon, and Giovanni Giacometti.
    ESEEM Study of the Active Site of Reduced Manganese Superoxide Dismutase from E. coli.
    Eurobic-6 Conference, Lund Sweden and Copenhagen Denmark July 29 to August 3, 2002
  52. T. Mavromoustakos, P. Zoumpoulakis, M. Zervou, I. Kyrikou, A. Kapou and N.P. Benetis.
    The Use of Computational Analysis to Design Novel Drugs.
    Computational Methods in Science and Engineering 2003 (ICCMSE 2003) Conference. Kastoria, Greece, September 12-16, 2003
  53. Nikolas-Ploutarch Benetis, Ioanna Kyrikou, and Thomas Mavromoustakos.
    Static 31P NMR Spectral Simulations of DPPC Bilayers in the Absence and Presence of the Bioactive Dipeptide b-Ala-Tyr or Glu.
    4th Hellenic Forum on Bioactive Peptides, Patras, April 22-24, 2004
  54. Agnes Kapou, Nikos Avlonitis, Anastasia Detsi, Maria Koufaki, Theodora Calogeropoulou, Nikolas P. Benetis and Thomas Mavromoustakos.
    CoMFA and CoMSIA 3D-Quantitative Structure-Activity Relationships of New Flexible Antileishmanial Ether Phospholipids.
    International Conference of Computational Methods in Sciences and Engineering 2004 (ICCMSE 2004) 19-23 November 2004. Accepted poster presentation and extended Abstract.

    University Editions
  55. Nikolas-Ploutarch Benetis.
    Nuclear-Spin Relaxation in Paramagnetic Metal Complexes and the Slow-Motion Problem for the Electron Spin.
    Ph. D. Thesis, University of Stockholm 1984
  56. Nikolas-Ploutarch Benetis.
    Quantum-Dynamics in Simple Spin Systems.
    Compendium, Universitetet i Linköping, 1989 (Rev. 1993).
    Latest revision, 1997
 
   

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