Curriculum Vitae

THOMAS MAVROMOUSTAKOS

FULL CV

Date of birth: 18/6/1960
Addresses:

1. National and Kapodistrian University of Athens, Zographou 15771, Chemistry Department, Athens, Greece
2. National Hellenic Research Foundation, Institute of Organic and Pharmaceutical Chemistry, 11635 Athens, Greece

Tel: +30 210 7274293 (University) +30 210 7273869 (NHRF/IOPC)
FAX: +30 210 7274261 (University) +30 210 7273872  (NHRF/IOPC)
e-mail: tmavrom@chem.uoa.gr  and tmavro
Family status: Married with four children

• EDUCATION

B.Sc.  1985  Chemistry, University of Athens, Greece.
M.Sc. 1988 Medicinal Chemistry, University of Connecticut
Ph.D. 1990, Medicinal Chemistry, University of Connecticut.
B.Sc. 2007, Theology, University of Athens, Greece

• EMPLOYMENT

1985-1987. Teaching Assistant in School of Pharmacy for introductory and advanced level courses.
1988-October 1990. Research Assistant in School of Pharmacy.
October 1990-June 1991 Postdoctoral Fellow in School of Pharmacy.
June 1991- August 2007 Research director of Laboratory of Molecular Analysis at the Institute of Organic and Pharmaceutical Chemistry (IOPC) of National Hellenic Research Foundation (NHRF). I still exerting research activity as scientific collaborator in the same laboratory.
September 2007- Associate Professor at University of Athens, Chemistry Department. Organic Chemistry section.

• RESEARCH INTERESTS 

a) Application of  physical chemical methodologies (Solid state and liquid NMR spectroscopy, DSC, Raman, x-ray diffraction) for
(ii) Study drug:membrane interactions
(iii) Perform conformational analysis to find the stereoelectronic requirements for drug activity.
(iιι)  Characterization of materials (zeoliths, bioinorganic complexes etc).
b) Use of 3D QSAR studies and Molecular Modeling to design novel AT1 antagonists and other classes of bioactive molecules.
c) Explore of the Cyprus plants for bioactive constituents (i.e. F. Sycomorus for psoralens).

d) Extend the knowledge of applications of NMR in medicine (use of MRI techniques) 

• PUBLICATIONS

a) Articles in peer reviewing journals -115-
b) Monagraphies and Books -23-
c) Patents -2-
d) Educational books written in Greek Language -6-
e) Editor in books published by IOS press -2-
f) Guest editor in current topics of Medicinal Chemistry and Clinical Pharmacology -3-
g) Articles in Greek journals -46-
h) Articles of General Scientific Interest -4-

• AWARDS

Recipient of  awards (Fullbright 1999, Academy of Athens 1998, Royal Society 1992, 2004);
Recipient of European and National  grants  -28-
Co-ordinator (2 European) 
Scientist in charge in bilaterals and national programs (8)
Participant (18)

• TEACHING EXPERIENCE

Organic and Pharmaceutical Chemistry courses at the Universities of Cypurs and Greece. Supervision of : 12 Ph.D and 13 MSc students 
Participation as a member in various committees for graduate students.

• REVIEWER

J. Med. Chem., Biorg. Med. Chem. ,Bioorg. Med. Chem. Lett., Biochim. Biophys. Acta,
Am. Oil. Chem. Soc.,Pharmacol., Res., J. Pharmaceut. Biomed., Mini Rev. Med.   Chem (editorial board), Curr. Med. Chem.,  Drug Design Reviews-Online (editorial  board, J. Agric. Food Chem., Journal of Computer-Aided Molecular Design, Letters in Organic Chemistry, Chemical Biology in Drug Design. .

• SOFTWARE

Co-author of part of  "Molecular Conceptor". This is a commercialized software dedicated in the Drug Design and Synthesis  by Synergix Ltd. The chapter I have been contributing is referred about the principles that govern Synthesis of drug molecules.

• CD CREATION

  CD creation with my research group of Laboratory of Molecular Analysis containing information on the "Olive Oil" , its role in the civilization and religion. This is created for being distributed when a meeting was organized in Athens in which participated all partners of European funded project  "GROWTH". This is included in the web site of the funded project and it is utilized by NHRF as a commercial product.

PUBLISHED RESEARCH ARTICLES 2009-2010

1. C. Potamitis, M Zervou,. V. Katsiaras, P Zoumpoulakis, S. Durdagi, M. Papadopoulos, J. Hayes, S. Grdadolnik, I. Kyrikou, D. Argyropoulos, G.Vatougia, T. Mavromoustakos. Antihypertensive Drug Valsartan in solution and at the AT1 Receptor: Conformational Analysis, Dynamic NMR Spectroscopy, in silico Docking and Molecular Dynamics Simulations. J. Chem. Inf. Mod. 49, 726-739 (2009).

2. C. Fotakis, D. Christodouleas, P. Chatzigeorgiou, M. Zervou, N. P. Benetis, K. Viras, T.M. Mavromoustakos. Application of a novel CP-31P NMR methodology to study the possible interdigitation effect of losartan in phospholipids bilayers. Comparison with Raman spectroscopy data Biophys. J. 96, 2227-2236 (2009).

3. C. Koukoulitsa, A.T. Kakoulidou, T. Mavromoustakos, I. Chinou. PLS Analysis for Antibacterial Activity of Natural Coumarins Using VolSurf Descriptors. QSAR Comb. Sci. 785-789 (2009).

4. Kotzabasakis, V., Kostakis, K., Pitsikalis, M., Hadjichristidis, N., L.D., David, Mavromoustakos, T., Potamitis, C. Polymerization of Higher α-Olefins Using a Cs-Symmetry Hafnium Metallocene Catalyst. Kinetics of the Polymerization and Microstructural Analysis. J. Polym. Sci. Part A 47, 4314-4325 (2009).

5. Durdagi S., Supuran, T., Amalda, T.S, Doostdar, N., Kumar, M.K., Barron, A.R., Mavromoustakos, T., Papadopoulos, M.G. In Silico Drug Screening Approach for the Design of Magic Bullets: A Successful Example with Anti-HIV Fullerene Derivatized Amino Acids. J. Chem. Inf. Model. 49, 1139-1143 (2009).

6. Aggeliki Politi, Serdar Durdagi, Panagiota Moutevelis-Minakakis, George Kokotos, Manthos G. Papadopoulos, Thomas Mavromoustakos. Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases. Eur. J. Med. Chem. 44(9) 3703-3711 (2009).

7. L. Mannina, M.D. Imperio, D. Capitani, S. Rezzi, C. Guillou, T. Mavromoustakos, M.D. Vilchez, A.H. Fernandez. 1H NMR-Based Protocol for the Detection of Adulterations of Refined Olive Oil with Refined Hazelnut Oil. J. Agr. Food Chem. 57(24) 11550-11556 (2009).

8. C. Fotakis, S. Gega, E. Siapi, C. Potamitis, K. Viras, P. Moutevelis-Minakakis, G. Kokotos, S. Durdagi, S. Grdadolnik, B. Sartori,M.Rappolt, T. Mavromoustakos. Drug interactions at the bilayer interface and receptor site induced by the novel synthetic pyrrolidinone analog MMK3. Biochim. Biophys. Acta 1798(3) 422-432 (2010)

9. V.D. Mouchlis, T.M. Mavromoustakos, G. Kokotos. Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor. J. Comput. Aided. Mol. Des. 24(2) 107-115 (2010).

10. S. Durdagi, M. Papadopoulos, P. Zoumpoulakis, C. Koukoulitsa; T. Mavromoustakos. A Computational Study on Cannabinoid receptors and Potent Bioactive Cannabinoid Ligands: Homology Modeling, Docking De novo Drug Design and Molecular Dynamics Analysis. Molecular Diversity 14(2) 257-276 (2010).