Βιογραφικό Σημείωμα

ΠΛΗΡΕΣ ΒΙΟΓΡΑΦΙΚΟ

Maria Micha-Screttas,
Research Director

Tel: +30 210 7273878
Fax: +30 210 7273877
E-mail: mskreta

Education
Diploma in Pharmacy, 1968 , University of Athens
PhD in Pharmaceutical Chemistry, 1972, University of Athens 

Employment
1972-1973                    Researcher, NRCPS ''Demokritos''
1973                            Researcher, National Hellenic Research Foundation
1985 (six months)         Visiting researcher, Wayne State Univ. of Detroit, Michigan
2000-present                Research Director,Institute of Biology, Medicinal Chemistry and Biotechnology, Division of Organic & Medicinal Chemistry (OMC)
July 2001-March 2003:   Acting Director of the Institute of Organic and Pharmaceutical Chemistry

Other Activities
2000-2002:                  Deputy Director of IOPC
April 2010-present:        Deputy Director of IOPC
2007-2008:                  Guest Editor of Current Topics in Medicinal Chemistry Title of the issue: ''Biomedical Applications of Dendrimers'' 2008, Vol. 8, No. 14

Research Interests
Over 30 years experience in the field of Organic and Organometallic Chemistry and especially in the study of paramagnetic organometallic compounds and radical anions by multinuclear NMR.

Current research interests are focused on the synthesis of :

- design and synthesis of novel organic-organometallic compounds with applications in material science such as compounds with non-linear optical properties and as near infrared dyes
- design and synthesis of bioactive molecules and specifically with antioxidant activity
- Recently we have initiated research activities in the field of dendrimer chemistry through the design and synthesis of new dendritic compounds with biomedical applications such as drug delivery systems, as potent neuroprotective agents acting as iron chelators, antibacterial activity. In parallel we plan exploit the newly synthesised dendritic molecules for applications in material science e.g for toxic metal complexation and in solid phase synthesis by increase the loading capacity of commercial available materials.

Recent Publications (2005-2010)

C.G. Screttas, G.A. Heropoulos, M. Micha-Screttas and B.R. Steele, Tetrahedron  Lett. 2005, 46, 4357-4360
''Medium-dependent lithiated side products in the reductive lithiation of allylic phenyl  thioethers. Diethyl ether versus tetrahydrofuran''

B.R. Steele, C. Villalonga-Barber, M. Micha-Screttas and C. G.  Screttas, Tetrahedron  Lett. 2006, 47, 2093-2097
''Selective catalytic carbanionic ethylation of methylphenols: influence of  catalyst and substitution pattern''

C. Villalonga-Barber, B.R. Steele, V. Kovac, M. Micha-Screttas and C.G. Screttas, J. Organomet. Chem. 2006, 691, 2785-92
''New stable, isolable triarylmethyl based dyes absorbing in the near infrared''

K. Gardikis, M. Micha-Screttas, B.R. Steele and C. Demetzos, Pharmakeftiki, 2006, I, IV, 89-92.
''An Overview of Dendrimers and their Biomedical Applications''

B. R. Steele, S. Georgakopoulos, M. Micha-Screttas and C. G. Screttas, Eur. J. Org. Chem. 2007, 3091-96.
''Synthesis of new sterically hindered anilines''

G.C. Skretas, A. Meligova, C. Villalonga-Barber, D. Mitsiou, M.N. Alexis, M. Micha-Screttas, B.R. Steele, C.G. Screttas and D. Wood, J.A.C.S, 2007, 129, 8443-57.
''Engineered chimeric enzymes as tools for drug discovery:Generating reliable bacterial screens for the detection, discovery and assessment of estrogen receptor modulators''

F. Wiesbrock, C. Patteux, T.K. Olszewski, A. Blanrue, G.A. Heropoulos, B.R. Steele, M. Micha-Screttas, and T. Calogeropoulou, Eur.J.Org.Chem. 2008, 4344-4349.
''Solution-Phase Synthesis and Scale-Up of 1st Generation Tetraester-Dendritic  Branches Involving Microwave Irradiation and/or Ultrasound''

C. Villalonga-Barber, M. Micha-Screttas, B.R. Steele, A. Georgopoulos and C. Demetzos, Curr. Top. Med. Chem, 2008, 8, 1294-1309.
''Dendrimers as Biopharmaceuticals: Synthesis and Properties''

M. Micha-Screttas, and H. Ringsdorf, Curr. Top. Med. Chem, 2008, 8, 1161-1164.
''Polymer Science and Polymer Therapeutics: Macromolecules, Dendrimers and Nanomedicine.''

K. Gardikis, S. Hatziantoniou, M. Bucos , D. Fesas, M. Signorelli, T. Felekis, M. Zervou , C.G. Screttas , B.R. Steele , M. Ionov , M. Micha-Screttas, B. Klajnert, M. Bryszewska, C. Demetzos. J.Pharm. Sci. 2010, 99, 3561-3571
''New Drug Delivery Nanosystem Combining Liposomal and  Dendrimeric Technology (Liposomal Locked-In Dendrimers) for Cancer Therapy''

M. Bucos, C. Villalonga-Barber, M. Micha-Screttas, B.R. Steele, C.G. Screttas, G.A. Heropoulos,  Tetrahedron, 2010, 66, 2061-2065
''Microwave assisted solid additive effects in simple dry chlorination reactions with N- chlorosuccinimide''

K. Gardikis; S. Hatziantoniou; M. Signorelli; M. Pusceddu; M. Micha-Screttas; A. Schiraldi; C. Demetzos; D. Fessas, Colloids and Surfaces B: Biointerfaces, 2010, Ref. No.: COLSUB-D-10-00352R1
''Thermodynamic and structural characterization of Liposomal-Locked in-Dendrimers as drug carriers''