My research activities are focused in the following scientific areas: Biomedical Engineering/Medical Informatics, Computational Biology and Bioinformatics.
My research interests in Biomedical Engineering and Medical Informatics involve biomedical signal processing, biomedical image processing and analysis, neural networks, telemedicine.
My research experience in Bioinformatics and Computational Biology concerns machine learning approaches and computational analysis of protein and genomic sequence data, data mining techniques, simulation methods to study critical aminoacids for protein folding, in silico modeling and study of protein - ligand interactions (e.g protein - ligand docking simulations, studying intermolecular interactions in complexes etc) in order to conduct in silico protein engineering experiments, and studying the three-dimensional arrangement of essential features (pharmacophore) that enable a molecule to exert a particular biological effect, for computational drug design purposes.
Other areas of research involve the development of practical web based databases and online tools for allowing the end users to conduct biocomputations (even computationally demanding ones) without having to think anything except the applications they use.
T Thireou, V Atlamazoglou, NA Papandreou, M Lonquety, J Chomilier, E Eliopoulos, "Quantitative Prediction of Critical Amino Acid Positions for Protein Folding", Protein & Peptide Letters, 2009 Sep 10. [Epub ahead of print] PMID: 19508208
T Thireou, V Atlamazoglou, M Levakis, E Eliopoulos, A Hountas, G Tsoucaris and K Bethanis, "CrystTwiV: a web-server for automated phase extension and refinement in X-ray crystallography", Nucleic Acids Research 2007; 35(Web Server issue): W718-722
T Thireou, M Reczko, "Bidirectional Long Short Term Memory Networks for Predicting the Subcellular Localization of Eukaryotic Proteins", IEEE Transactions on Computational Biology and Bioinformatics 2007; 4(3): 441-446
V Atlamazoglou, T Thireou and E Eliopoulos "Using a pharmacophore representation concept to elucidate molecular similarity of dopamine antagonists" Journal of Computer-Aided Molecular Design 2007; 21(5): 239-249
V Atlamazoglou, T Thireou, Y Hamodrakas, G Spyrou, " MetaBasis: A web based database (Basis) containing metadata (Meta) on software tools and databases in the field of Bioinformatics", Applied Bioinformatics 2006; 5 (3): 187-192
İ National Hellenic
Research Foundation (NHRF), 48 Vassileos Constantinou Ave., 11635 Athens,
Greece, Tel. +302107273700, Fax. +302107246618