M.Sc. Telecommunications / RF engineering, Dept. of Physics, U of Athens
B.Sc. Physics, Dept. of Physics, U of Athens
NMR spectroscopy in solution and in solid phase
Conformational analysis and in silico binding studies
(a) Assessment of the bioactive conformations of biologically active compounds and mapping of their binding site interactions with a specific target.
Studies have been applied to antihypertensive analogs (AT1 antagonists), novel derivatives of the neurosteroid hormone DHEA with antiapoptotic and neuroprotective activity, labdane-type diterpenes
with anti-inflammatory, cytotoxic and cytostatic activity
(b) Structure elucidation of novel bioactive compounds from natural sources (plant or marine origin)
(c) Metabolic profile monitoring of natural products (alcoholic beverages, olive oil) using HR NMR
spectroscopy and multivariate statistical analysis.
(d) Biophysical studies of membrane:drug interactions (i.e. AT1 antagonists with DPPC bilayers) using solid state NMR spectroscopy
Co-author in 30 publications and 3 review articles in peer-review international journals, 5 chapters in international edition books, a patent, and several written/oral participations in international and national conferences.
Participation in 4 EU research programs, 3 bilateral collaborations, 3 National programs and 2 EU networks.
Supervisor of a Ph.D thesis and an M.Sc thesis. Participation in scientific committees of PhD and MSc students. Training of students and young researchers who have accomplished their diploma work, MSc and PhD theses in the Laboratory of Molecular Analysis.
Design and implementation of ''SoftCRM'', statistical s/w for the certification process of Reference Materials.
Recent selected publications
Gardikis K., Hatziantoniou S., Bucos M., Zervou M., Screttas C.G., Steele B.R., Ionov M., Micha-Screttas M., Fessas, Demetzos C. Development and characterization of a new drug delivery nanosystem combining liposomal and dendrimeric technology (liposomal locked-in dendrimers) for cancer therapy. J Pharm Sci 2010 99(8), 3561-3571
Politi A., Zervou M., Triantafyllidi H., Zoumpoulakis P., Zoga A., Moutevelis-Minakakis P., Kokotos G., Mavromoustakos T., Iliodromitis E.K., Kremastinos D.Th.. Hypertension study in anesthetized rabbits: Protocol proposal for AT1 antagonists screening. JRAAS 2010, 11 (2), 103 - 110
Calogeropoulou T., Avlonitis N., Minas V., Alexi X., Pantzou A., Charalampopoulos I., Zervou M., Vergou V., Katsanou E. S., Lazaridis I., Alexis M., Gravanis A. Novel DHEA Derivatives with Anti-Apoptotic Neuroprotective activity. J. Med. Chem. 2009, 52 (21), 6569-6587
Ioannou E., Zervou M., Ismail A., Ktari L., Vagias C., Roussis V. 2,6-Cyclo-xenicanes from the brown algae Dilophus fasciola and Dilophus spiralis. Tetrahedron 2009, 65 10565-10572
C. Potamitis, M. Zervou, V. Katsiaras, P. Zoumpoulakis, S. Durdagi, M. G.Papadopoulos, J. M. Hayes, S.Golic Grdadolnik, I. Kyrikou, D. Argyropoulos, G. Vatougia, T. Mavromoustakos. Antihypertensive Drug Valsartan in solution and at the AT1 Receptor: Conformational Analysis, Dynamic NMR Spectroscopy, in silico Docking and Molecular Dynamics Simulations. J. Chem. Inf. Model. 2009; 49, 726-739
Ch. Fotakis, D. Christodouleas, P. Chatzigeorgiou, M. Zervou, N. P. Benetis, K. Viras, T. Mavromoustakos. Development of a CP-31P NMR broadline simulation methodology for studying the interactions of antihypertensive AT1 antagonist losartan with phospholipids bilayers. Biophysical J. 2009; 96, 2227-2236
E. Ioannou, A. F. Abdel-Razika, M. Zervou, D. Christofidis, X. Alexi, C. Vagias, M. N. Alexis, V. Roussis. 5á,8á Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity. Steroids 2009; 74, 73-80