Dr. Spyros E. Zographos
Institute for Biology, Pharmaceutical Chemistry & Biotechnology
Department for Organic & Medicinal Chemistry (OMC)
Academic formation 1992 Diploma in Chemistry, Dept. of Chemistry, University of Athens 1997 PhD in Chemistry, Dept. of Chemistry, University of Athens
1992-1997: PhD fellowship, National Hellenic Research 2001-2004: Marie Curie Post Doctoral fellowship 2004-2005: Marie Curie Post Doctoral fellowship
1999-2000 Post-doctoral Research Fellow, Institute of Biological Research and
Biotechnology (IBRB), NHRF 2000-2001 Visiting Lecturer, Department of Chemistry, University of Cyprus 2001-2004 Post-doctoral Research Fellow, Department of Biological Sciences, University of Cyprus 2004-2006 Post-doctoral Research Fellow, Institute of Organic and Pharmaceutical Chemistry (IOPC), NHRF 2006-2009Research Assistant, IOPC, NHRF
His main fields of specialization are biochemistry, molecular biology, enzyme kinetics, X-ray protein crystallography and structure-based drug design. His major research interests are focused on functional and structural studies of enzymes involved in type 2 diabetes mellitus (glycogen phosphorylase, phosphorylase kinase, glucokinase and phosphoenolpyruvate carboxykinase), nucleotide homeostasis (Adenylate kinase 6) and transmission of malaria (Odorant Binding Proteins from mosquito Anopheles gambiae).
Synopsis of scientific achievements
His scientific achievements are presented in 51 peer-reviewed articles (h-index: 21, i10-index: 37 Times Cited: total 1,299, without self-citations: 1.113), 3 reviews, 3 chapters in books, 40 oral /poster presentations in conferences and 21 short communications (Source: WoS & Google Scholar http://scholar.google.com/citations?user=-zAUuCoAAAAJ&hl=en). Five of his articles were presented in the cover of the respective issues of scientific journals Proteins, Acta Crystallographica F, Bioorganic & Medicinal Chemistry, European Journal of Biochemistry and Protein Science.
Dr. Zographos is registered user (since 1992) of the European Synchrotron Radiation Sources, Daresbury Laboratory, Daresbury, UK, Sinchrotrone Trieste, Trieste, Italy, EMBL, Hamburg-Outstation, DESY and Lund-MaxLab, and has carried out 48 visits (more than 500 shifts) for X-ray crystallographic data collection through grant applications. He has deposited more than 100 structures with the PDB (Structure author).
Dr. Zographos has significant teaching experience: As a visiting lecturer at the Chemistry Department of University of Cyprus, he taught Medicinal Chemistry, Biochemistry, X-ray Protein Crystallography (undergraduate courses) and Enzymology-Structural Biology as part of a postgraduate course. Furthermore, he has been co-organizer and/or tutor for eight workshops and two international scientific symposiums on structure-based drug design. He has supervised 4 MSc and 2 final year research projects and currently is supervising 1 PhD Thesis and 1 MSc research project.
His current research activities are supported by the EU-FP7 competitive programs
''ENAROMaTIC: European Network for Advanced Research on Olfaction for Malaria Transmitting Insect Control.'' FP7-HEALTH-2007-2.3.2-9, (GA-222927), (1/12/2008-30/11/2012); Coordinator Dr. K. Iatrou, NCR Demokritos. Budget Total/for PI: 2,500,000/280,000 €. Role: SBCG Principal Investigator
''ARCADE: Advancement of Research Capability for the Development of New Functional Compounds'' FP7-REGPOT-2009-1, (GA-245866), (01/12/2009-30/5/2013); Coordinator Dr. B. Steele, IBMCB/ NHRF.
Budget Total/for SBCG/ for PI : 2,000,000/215,000 €/115,000 € Role: SBCG Principal Investigator.
ENAROMaTIC consortium which aims to reduce malaria transmission rates consists of ten institutions from 7 EU countries, 1 from USA and 1 from Nigeria. The current list of Dr. Zographos' collaborators also includes research teams from Japan and China.
Other scientific activities
He is a Member of Greek Chemists' Association, Hellenic Society of Biochemistry and Molecular Biology, American Society of Molecular Biology and Biochemistry, Treasurer of the Board of the Hellenic Crystallographic Association and permanent board member of the ''Nikos Oikonomakos award'' for structural biology.