INSTITUTE OF BIOLOGY, MEDICINAL CHEMISTRY & BIOTECHNOLOGY

 

NMR SPECTROSCOPY FACILITY

Installed in July 2007
Funding: OPERATIONAL PROGRAMME "COMPETITIVENESS", Measure 4.5, Action 4.5.1: INFRASTRUCTURE TO SUPPORT  THE LONG TERM VIABILITY OF RESEARCH ACTIVITIES, TECHNOLOGICAL PROMOTION AND DISSEMINATION.
Project title: DESIGN AND SYNTHESIS OF BIOACTIVE COMPOUNDS



Varian V600 MHz

Upgraded with 3rd channel accessory & 1H/13C/15N triple resonance probe in October 2010
FP7-REGPOT-2009-1

 

Features:
Magnet:
14.1 Tesla 54 mm bore Varian Superconducting Magnet

Console:
DIRECTDRIVE ARCHITECTURE INCLUDING POWER PC AND XILINX FPGA. Provides total pulse programming control and delivers precisely timed RF events. Complete waveform shaping capability.
3 RF Channels
Channel 1 is highband, with 1H/19F observe, spinlock and decouple capability (550-600 MHz, 50W)
Channels 2 & 3 have broadband observe, spinlock and decouple capability (18-245 MHz, 300 W)

• Performa IV Pulsed Field Gradient Module
• Protune Accessory
• Variable Temperature unit (-150C to +250C, with 0.1C resolution)

Probes:
• 1H{13C/15N} 5mm PFG Automatable Triple Resonance
• 1 H{15N- 31P} 5 mm PFG AutoX Indirect Detect 600
• 1 H-19F/15N- 31P 5mm PFG AutoX DB600
• 4mm Nanoprobe (gHX 8 15W- 31P[1H] )
Host computer: Dell 380N PC, Red Hat Linux
Software: VNMRJ 2.2C

Applications
• Single or double resonance studies to fully characterize organic compounds
• DOSY pulse sequence for the separation of mixture components
• Triple resonance experiments of chemical or biomolecular samples. Capability for 1H observation with simultaneous or single irradiation of 13C and 15N frequencies.

 

Varian V300 MHz

Features:
Magnet:
7 Tesla 52 mm bore Oxford Magnet

Console:
DIRECTDRIVE ARCHITECTURE INCLUDING POWER PC AND XILINX FPGA. Provides total pulse programming control and delivers precisely timed RF events. Complete waveform shaping capability.

2 RF Channels
Channel 1 is highband, with 1H/19F observe, spinlock and decouple capability (200-300 MHz, 50W)
Channels 2 has broadband observe, spinlock and decouple capability (12-220 MHz, 300 W and 220-245 MHz, 150 W)

• Performa I Pulsed Field Gradient Module
• Carousel autosampler for 9 samples
• Variable Temperature unit (-15oC to +25oC, with 0.1oC resolution)

Probes:
1 H/19F/31P/13C 5mm PFG AutoSwitchable
Host computer: Dell 380N PC, Red Hat Linux
Software: VNMRJ 2.2C

Applications
• Single or double resonance studies to fully characterize organic compounds

 

Varian V400 MHz Solid state

Features:
Magnet:
9.4 Tesla WB 89 mm bore Oxford Magnet

Console:
DIRECTDRIVE ARCHITECTURE INCLUDING POWER PC AND XILINX FPGA. Provides total pulse programming control and delivers precisely timed RF events. Complete waveform shaping capability.

2 RF Channels
Channel 1 is highband, with 1H/19F observe, spinlock and decouple capability (400 MHz, 1 KW)
Includes X-HP Solids Single Cabinet
Channels 2 has broadband observe, spinlock and decouple capability (12-220 MHz, 1 KW and 220-240 MHz, 850 W)

• Performa I Pulsed Field Gradient Module
• Variable Temperature unit (-50oC to +100oC, with 0.1oC resolution)
Mass speed controller

Probes:
3.2 mm Double Resonance HX-Mas Solids probe

25 KHz MAS spinning, 31P to 15N observe channel 19F-1H Decouple channel, 147 KHz decoupling strength

Host computer: Dell 380N PC, Red Hat Linux
Software: VNMRJ 2.2C

Applications

  • 13C, 31P MAS and CP-MAS with HP 1H decoupling
  • Drug-membrane interactions
  • Determination of coordination states of 27Al, 29Si
  • Drug polymorphism studies
  • Characterization of other metal complexes

 

Prices

Pricelist [pdf]

Samples should be submitted to :

NMR services, Laboratory of Molecular Analysis, Division of Organic and Division Chemistry, National Hellenic Research Foundation, Vas. Constantinou 48, 11635, Athens, Greece

Tel. +30210.72.73.870
Fax. +30210.72.73.872
Email: mzervou@eie.gr, pzoump@eie.gr

Confidentiality agreement

Laboratory personnel is very experienced in dealing with samples of a confidential nature. Confidentiality can be ensured either on an informal basis or by contracting a customized "non disclosure" agreement.


 
 

National Hellenic Research Foundation (NHRF), 48 Vassileos Constantinou Ave., 11635 Athens, Greece, Tel. +302107273700, Fax. +302107246618