Recent Publications

J.M. Matsoukas, L. Polevaya, J. Ancas, T. Mavromoustakos, A. Kolocouris, P. Roumelioti, D.V. Vlahakos, R. Yamdagni, Q. Wu, G.J. Moore. (2000). The Design and Synthesis of a Potent Angiotensin II Cyclic Analogue Confirms the Ring Cluster Receptor Conformation of the Hormone Angiotensin II, Bioorganic and Medicinal Chemistry 8, 1-10.

A. Troganis, I.P. Gerothanasis, Z. Athanassiou, T. Mavromoustakos, G.E. Hawkes, C. Sakarellos. (2000). Thermodynamic Origin of Cis/Trans Isomers of a Proline-Containing β-turn Model Dipeptide in Aqueous Solution: A Combined Variable Temperature 1H-NMR, Two Dimensional 1H, 1H Gradient Enhanced Nuclear Overhauser Effect Spectroscopy (NOESY), One Dimensional Steady-State Intermolecular 13C, 1H-NOE and Molecular Dynamics Study. Biopolymers 53, 72-83.

P. Roumelioti, T. Tselios, K. Alexopoulos, T. Mavromoustakos, A. Kolocouris, G.J. Moore, J.M. Matsoukas. (2000). Structural comparison between type I and type II antagonists: possible implications in the drug design of AT-1 antagonists. Biorganic and Medicinal Chemistry Letters 10 755-758.

T. Mavromoustakos, M. Zervou, G. Bonas, A. Kolocouris, P.Petrakis. (2000).A Novel Analytical Method to Detect Adulteration of Virgin Olive Oil by Other Oils. J Am Oil Chem Soc 77(4) 405-411.

T. Tselios, I. Daliani, S. Deraos, S. Thymianou, E. Matsoukas, I. Gerothanasis, A. Troganis, A. Mouzaki, T. Mavromoustakos, L. Probert, J. Matsoukas. (2000). Treatment of Experimental Allergic Encephalomyelitis (EAE) by a Rationally Designed Cyclic Analogue of Myelin Basic Protein (MBP) Epitope 72-85. Biorganic and Medicinal Chemistry Letters 10 2713-2717.

K. Dimas, C. Demetzos, D. Angelopoulou, A. Kolokouris, T. Mavromoustakos. (2000). Biological Activity of Myricetin and Derivatives Against Human Leukemic Cell Lines in vitro. Pharmacological Research, 42(5) 475-478.

Antonios Kolocouris, T. Mavromoustakos, Costas Demetzos, Aris Terzis, Simona Golic Grdadolnik. (2000). Structure Elucidation and Conformational Properties of a Novel Bioactive Clerodane Diterpene Using a Combination of High Field NMR Spectroscopy, Computational Analysis and X-Ray Diffraction. Biorg. Med. Chem. Lett. 11837-840.

Yoshiteru Itagaki, Nikolas P. Benetis, Ramakant M. Kadam and Anders Lund. (2000). Structure of Dimeric Radical Cations of Benzene and Toluene in Halocarbon Matrices: ESR, ENDOR and MO Study. Phys. Chem. Chem. Phys. 2 2683-2689.

H. Yahiro, A. Lund, N. P. Benetis and M. Shiotani. (2000). An EPR Study on Nitrogen Monoxide Adsorbed on Sodium Ion-Exchanged A-type Zeolite. Chemistry Letters, Chemical Society of Japan, , 736-737.

Nikolas P. Benetis and Anders R. Sornes. (2000). Automatic Spin-Hamiltonian Diagonalization for Electronic Doublet Coupled to Anisotropic Nuclear Spins Applied in One- and Two-Dimensional ESE Simulations. Concepts in Magnetic Resonance 12:6 410-433.

Hidenori Yahiro, Anders Lund, Roland Aasa, Nikolas P. Benetis, and Masaru Shiotani. (2000).Association Forms of NO in Sodium Ion-exchanged A-type Zeolite: Temperature-dependent Q-band EPR spectra. J. Phys. Chem. A. 104:34 7950-7956.

K. Alexopoulos, D. Panagiotopoulos, T. Mavromoustakos, P. Fatseas, M.C. Paredes-Carbajal, D. Mascher, S. Mihailescu, J. Matsoukas. (2001). Design, Synthesis and Modeling of Novel Cyclic Thrombin Receptor Derived Peptide Analogues of the Ser42-Phe-Leu-Leu-Arg46 Motif Sequence with Fixed Conformations of Pharmacophoric Groups: Importance of a Phe/Arg/NH2 Cluster for Receptor Activation and Implications in the Design of Non-Peptide Thrombin Receptor Mimetics. J. Med. Chem. 44, 328-339.

T. Mavromoustakos, V. Apostolopoulos, J. Matsoukas. (2001) Antihypertensive drugs that act on Renin-Angiotensin System with emphasis in AT1 antagonists. Mini Rev. in Med. Chem. 1, 207-217.

J. Matsoukas, T. Mavromoustakos, V. Apostolopoulos. (2001). Designing peptide mimetics for the treatment of multiple sclerosis. Mini Rev. Med. Chem. 1, 273-282.

M. Matzapetakis, M. Kourgiantakis, M. Dakanali, C. P. Raptopoulou, A. Terzis, A. Lakatos, I. Banyai, T. Kiss, L. Iordanidis, T. Mavromoustakos, A. Salifoglou. (2001). Synthesis, pH-dependent Structural Characterization and Solution Behavior of Aqueous Aluminum and Gallium Citrate Complexes. Inorg. Chem. 40, 1734-1744.

T. Mavromoustakos, D. Papahatjis, P. Laggner. (2001). Differential Membrane Fluidization by Active and Inactive Cannabinoid analogs. Biochim. Biophys. Acta 1512(2) 183-190.

L. Polevaya, T. Mavromoustakos, P. Zoumboulakis, S. G. Grdadolnik, P. Roumelioti, N. Giatas, Ilze Mutule, T. Keivish, D. Vlahakos, E. Iliodromitis, D. Kremastinos, J. Matsoukas. (2001). Synthesis and Study of Cyclic Angiotensin II Antagonist Analogue reveals the role of π*-π* interactions in the C-Terminal Aromatic Residue for agonist activity and its structure resemblance with AT1 non-peptide antagonists. Bioorg. Med. Chem. 9 1639-1647.

T. Mavromoustakos, T. Kalogeropoulou, M. Koufaki, A. Kolocouris, I. Daliani, C. Demetzos, Z. Meng, A. Makriyannis, J. Balzarini, E. De Clercq. Synthesis, Conformational and Thermotropic Properties of Ether Phospholipid AZT Conjugates. J. Med. Chem. 44 1702-1709 (2001). D. Angelopoulou, C. Demetzos, A. Kolocouris, I. Daliani, T. Mavromoustakos. (2001). Structure Elucidation, Conformational Analysis and Thermal Effects of Αntimicrobial Myricetin Derivatives on Membrane Bilayers. J. Heter. Chem. 38, 703-710.

C. Pappas, P.A. Tarantilis, I. Daliani, T. Mavromoustakos, M. Polysiou. (2002). Comparison of classical and ultrasound assisted isolation procedures of cellulose from Kenaf and Eucalyptus. Ultrason Sonochem, 9(1):19-23 .

T. Tselios, V. Apostolopoulos, I. Daliani, S. Deraos, S. Grdadolnik, T. Mavromoustakos, M. Melachrinou, S. Thymianou, A. Mouzaki and J. Matsoukas. (2002). Antagonistic Effects of Human Cyclic MBP87-99 Altered Peptide Ligands in Experimental Allergic Encephalomyelitis and Human T-cell Proliferation. J. Med. Chem. 45, 275-283.

P. Zoumpoulakis, S.G. Grdadolnik, J. Matsoukas. T. Mavromoustakos. (2002). Structure elucidation and conformational properties of eprosartan a non peptide Angiotensin II AT1 antagonist. J. Pharmaceut. Biomed. 28, 125-135.

H. Maswadeh, C. Demetzos, K. Dimas, Y. L. Loukas, A. Georgopoulos, T. Mavromoustakos, C. Th. Papaiouannou. (2002). In vitro cytototoxic/cytostatic activity of anionic liposomes containing vinblastine against leukemic human cells. J. Pharm. Pharmac. 54, 189-196

S. Prispas, E.S. Kioulafa, N. Hadjichristidis, T. Mavromoustakos. (2002). Block copolymers with crystalline-amorphous, crystalline-polyeloctrolyte and amorphous-polyelectrolyte blocks. Macromolecular Chemistry and Physics 203(10-11), 1317-132.

P. Roumelioti, L. Polevaya, P. Zoumpoulakis, N. Giatas, T. Keivish, A. Haritonova, A. Zoga, D. Vlahakos, E. Iliodromitis, D. Kremastinos, S.G. Grdadolnik, T. Mavromoustakos, J. Matsoukas. (2002).Design, Synthesis and Biological Evaluation of Cyclic Angiotensin II Analogues with 3,5 Side Chain Bridges: Role of C-Terminal Aromatic Residue and Ring Cluster for Activity and Implications in the Drug Design of AT1 non Peptide Antagonists. Bioorg. Med. Chem. Letters 12, 2627-2633.

Maswadeh H, Demetzos C, Daliani I, Kyrikou I, Mavromoustakos T, Tsortos A, Nounesis G. (2002).A molecular basis explanation of the dynamic and thermal effects of vinblastine sulfate upon dipalmitoylphosphatidylcholine bilayer membranes. Biochim. Biophys. Acta 1567 49-55.

Apostolopoulos V, Matsoukas J, Plebanski M, Mavromoustakos T. (2002). Applications of Peptide Mimetics in Cancer. Current Medicinal Chemistry, 9, 411-420.

Nikolas P. Benetis, Paresh Dave, and Daniella Goldfarb. (2002).Characteristics of ESEEM and HYSCORE Spectra of Higher Electron-Spin Multiplets (S >1/2) in Orientationally Disordered Systems. J. Magn. Res. 158 126-142

N. Avlonitis, E. Lekka, A. Detsi, M. Koufaki, T. Calogeropoulou, E. Scoulica, E. Siapi, I. Kyrikou, T. Mavromoustakos, A. Tsotinis, S. Golic Grdadolnik, A. Makriyannis. (2003). Antileshmanial Ring-Substituted Ether Phospholipids. J. Med. Chem. 46, 755-767.

P. Zoumpoulakis, A. Zoga, P. Roumelioti, N. Giatas, S.G. Grdadolnik, E. Iliodromitis, D. Vlahakos, D. Kremastinos, J. Matsoukas, T. Mavromoustakos. (2003). Conformational and biological studies for a pair of novel synthetic AT1 antagonists. Stereoelectronic requirements for antihypertensive efficacy. J. Pharmaceut. Biomed. 31 833-844.

I. Kyrikou, S.G. Grdadolnik, M. Tatari, C. Poulos, T. Mavromoustakos. (2003). Structure Elucidation and Conformational Properties of Toxin Paralysin β-Ala-Tyr. J. Pharmaceut. Biomed. 31, 713-721.

P. Moutevelis-Minakakis, M. Gianni , H.Stougiannou , P. Zoumpoulakis, A.Zoga, A. D. Vlahakos, E. Iliodromitis, T. Mavromoustakos (2003). Design and Synthesis of Novel Antihypertensive Drugs. Bioorg. Med. Chem. Letters 13(10), 1737-1740 .

M. Dakanali, E.T. Kefalas, C. P. Raptopoulou, A. Terzis, T. Mavromoustakos, A. Salifoglou. (2003). Synthesis, Spectroscopic, and Structural Studies of a New Cadmium (II)-Citrate Aqueous Complex. Potential links to Cadmium toxicity. Inorganic Chemistry 42, 2531-2537.

M. Dakanali, E.T. Kefalas, C.P. Raptopoulou, A. Terzis, G. Voyiatzis, I. Kyrikou, T. Mavromoustakos, A. Salifoglou. (2003). A New Dinuclear Ti(IV)-Peroxo-Citrate Complex from Aqueous Solutions. Synthetic, Structural, and Spectroscopic Studies in Relevance to Aqueous Titanium(IV)-Peroxo-Citrate Speciation. Inorganic Chemistry 42, 4632-4639.

P. Zoumpoulakis, I. Daliani, M. Zervou, I. Kyrikou, E. Siapi, G. Lamprinidis E. Mikros, T. Mavromoustakos. (2003). Losartan's molecular basis of interaction with membranes and AT1 receptor. Chem. Phys. Lipids 125, 13-25.

R. Kokkinofta, P. Petrakis, T. Mavromoustakos, C.R. Theocharis. (2003). Authenticity of the traditional Cypriot spirit "Zivania" on the basis of metal content. J. Agr. Food Chem. 125(1), 13-25.

M. Tsoukatou; H. Siapi; C. Vagias; V. Roussis. (2003). New Sesterterpene Metabolites from the Mediterranean Sponge Cacospongia scalaris. J. Nat. Prod.; 66(3); 444-446.

G. Bonas, M. Zervou, T. Papaeoannou and M. Lees. (2003). ''SoftCRM'': A new Software for the Certification of Reference Materials. Accredit Qual Assur, 8:101-107

A.N. Batsoulis, M.K. Nacos, C.S. Pappas, P.A. Tarantilis, T. Mavromoustakos, M.G. Polissiou. (2004). Determination of uronic acids in isolated hemicelluloses from kenaf using diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and curve-fitting deconvolution method. Applied Spectroscopy 58(2) 199-202.

I. Kyrikou, I. Daliani, T. Mavromoustakos, H. Maswadeh, C., Demetzos, S Xatziantoniou, S. Giatrellis, G. Nounesis. (2004). The modulation of thermal and dynamic properties of vinblastine by cholesterol in membrane bilayers. Biochim. Biophys. Acta. 1661, 1-8.

K. Alexopoulos, P. Fatseas, E. Melissari, D. Vlahakos, P. Roumelioti, T. Mavromoustakos, S. Mihailescu, M. Christina, P. Carbajal, D. Mascher, J. Matsoukas.(2004) Design and Synthesis of Novel Biologically Active Thrombin Receptor Non Peptide Mimetics Based on the Pharmacophoric Cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Arg46 Motif Sequence: Platelet Aggregation and Relaxant Activities. J. Med Chem. 17;47(13),3338-52.

T. Mavromoustakos, P. Zoumpoulakis, I. Kyrikou, A. Zoga, E. Siapi, M. Zervou, I. Daliani, D. Dimitriou, A. Pitsas, C. Kamoutsis, P. Laggner. (2004). Efforts to Understand the Molecular Basis of Hypertension Trough Drug:Membrane Interactions. Current Topics in Medicinal Chemistry, 4, 385-401.

T. Mavromoustakos, M. Zervou, P. Zoumpoulakis, I. Kyrikou, N.P. Benetis, L. Polevaya, P. Roumelioti, N. Giatas, A. Zoga, P. Moutevelis Minakakis, A. Kolocouris, D. Vlahakos, S. Golic Grdadolnik, J. Matsoukas. (2004). Conformation and Bioactivity. Design and Discovery of Novel Antihypertensive Drugs. Current Topics in Medicinal Chemistry,4, 445-459.

K.P. Marathias, B. Agroyannis, T. Mavromoustakos, J. Matsoukas, D.V. Vlahakos. (2004). Hematocrit-lowering Effect Following Inactivation of Renin-Angiotensin System with Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers. Current Topics in Medicinal Chemistry, 4, 483-486.

T. Mavromoustakos, A. Kapou, N.P. Benetis, M. Zervou. (2004).Conformational Analysis Using 2D NMR Spectroscopy Coupled with Computational Analysis as an Aid in the Alignment Procedure of 3D-QSAR studies. Drug Design Reviews - Online, 1(3), 235-245(11).

D. Kovala-Demertzi, C. Vidjeluc, M.A. Demertzis, E. Siapi, T. Mavromoustakos. (2004). The thermal effects of platinum (II) and palladium(II) complexes with 2-acetyl pyridine and pyridine-2-carbaldehyde N(4)-ethyl-thiosemicarbazones in membrane bilayers. Thermochimica Acta, 424(1-2), 53-58.

I. Kyrikou, D. Kovala, S. Xadjikakou, K. Viras, T. Mavromoustakos. (2004). Effects on non steroid anti-inflammatory drugs in membrane bilayers containing cholesterol, Chem Phys Lipids. 132(2), 157-69

K.S. Triantafyllidis, L. Nalbandian, P.N. Trikalitis, A.K. Ladanos, T. Mavromoustakos, C.P. Nicolaides (2004). Structural, compositional and acidic characteristics of nanosized amorphous or partially crystalline ZSM-5 zeolite-based materials. Microporous and Mesoporous Materials 75, 89-100

I. Kyrikou, T. Mavromoustakos, S. Xatziantoniou, A. Georgopoulos, C. Demetzos (2005). A comparative study of the effects of cholesterol and sclareol, a bioactive labdane diterpene, on phospholipids bilayers, Chem and Phys of Lipids 133, 125-134

E. Siapi, T. Mavromoustakos, V.Trandafir , B. Albu and P. Budrugeac (2005). The Use of Differential Scanning Calorimetry to Study the Effects of Gentamycin on Fibrous Collageneous Membranes. Thermochimica Acta 425, 165-171

J. Matsoukas, V. Apostolopoulos, H. Kallbacher, A.M. Papini, T. Tselios, K. Chatzantoni, T. Biagioli, F. Lolli, S. Deraos, P. Papathanassopoulos, T. Mavromoustakos, A. Mouzaki. (2005). Enhanced Stability and Biological Properties of Myelin Basic Protein Epitope 87-99 Cyclic Mimics Render Them a Potentially New Class of Immunomodulators J. Med. Chem. 48,1470-1480

A. Kapou, T. Mavromoustakos, S. Nikolaropoulos, (2005). Thermal Effects of Steroidal Carriers of Alkylating Agents On DPPC Membrane Bilayers. Thermochimica Acta 429, 53-56

E.T. Kefalas, P. Panagiotidis, C.P. Raptopoulou, A. Terzis, T. Mavromoustakos, A. Salifoglou. (2005). Mononuclear Titanium(IV)-Citrate Complexes from Aqueous Solutions:pH-Specific Synthesis and Structural and Spectroscopic Studies in Relevance to Aqueous Titanium(IV)-Citrate Speciation. Inorg. Chem. 44, 2596-2605

Nikolas-P. Benetis, Ioanna Kyrikou, Thomas Mavromoustakos, Maria Zervou. (2005). . Static 31P CP NMR Multilamellar Bilayer Broadlines in the Absence and presence of the Bioactive Dipeptide beta-Ala-Tyr and Comparison with Glu, Chemical Physics 314(1-3) 57-72

A. Kapou, M.A. Fousteris, S.S. Nikolaropoulos, M. Zervou, S.G. Gardadolnik, P. Zoumpoulakis, I. Kyrikou, T. Mavromoustakos.(2005) 2D NMR and conformational analysis of a prototype anti-tumor steroidal ester. J. Pharmaceut. Biomed (in press).

E.T. Kefalas, M. Dakanali, P. Panagiotidis, C.P. Raptopoulou, A. Terzis, T. Mavromoustakos, I. Kyrikou, N. Karligiano, A. Bino, A. Salifoglou.(2005) pH-Specific Aqueous Synthetic Chemistry in the Binary Cadmium(II)-Citrate System. Gaining Insight into Cadmium(II)-Citrate Speciation with Relevance to Cadmium Toxicity. Inorg. Chem. (in press).

P. Petrakis, I. Touris, M. Liouni, M. Zervou, C.R. Kokkinofta, R. Theocharis, T. Mavromoustakos (2005). Authenticity of the traditional Cyprus spirit "Zivania" on the basis of 1H NMR Spectroscopy Diagnostic Parameters and Statistical Analysis J. Agric. Food Chem, (in press)