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Organic and Organometallic Chemistry



Peer Reviewed Publications


M. Koufaki, T. Fotopoulou, G. A. Heropoulos, Ultrason. Sonochem., 2014, 21, 35–39; “Synergistic effect of dual-frequency ultrasound irradiation in the one-pot synthesis of 3,5-disubstituted isoxazoles”

K. C. Prousis, N. Avlonitis, G. A. Heropoulos and T. Calogeropoulou, Ultrason. Sonochem. 2014, DOI: 10.1016/j.ultsonch.2013.10.018; “FeCl3-catalysed ultrasonic-assisted, solvent-free synthesis of 4-substituted coumarins. A useful complement to the Pechmann reaction”

A. Pournara, D. Kovala-Demertzi, N. Kourkoumelis, S. Georgakopoulos, I.D. Kostas Catal. Commun. 2014, 43, 57-60 “Platinum/3,3´-thiodipropionic acid nanoparticles as recyclable catalysts for the selective hydrogenation of trans-cinnamaldehyde”

V. J. Sinanoglou, P. Zoumpoulakis, G. A. Heropoulos, C. Proestos, A. Ćirić, J. Petrovic, J. Glamoclija, M. Sokovic, J. Food Sci. Technol., 2014 (accepted for publication), “Lipid and fatty acid profile of the edible fungus Laetiporus sulphurous. Antifungal and antibacterial properties”



K. A. Vallianatou, D. J. Frank, G. Antonopoulou, S. Georgakopoulos, E. Siapi, M. Zervou, I.D. Kostas, Tetrahedron Lett. 2013, 54 (5), 397-401; “Rhodium-catalyzed asymmetric olefin hydrogenation by easily accessible aniline- and pyridine-derived chiral phosphites”

P. Pongrácz, I.D. Kostas, L. Kollár, J. Organomet. Chem. 2013, 723, 149-153 “Platinum complexes of P,N- and P,N,P-ligands and their application in the hydroformylation of styrene”

C. Villalonga-Barber, K. Vallianatou , S. Georgakopoulos, B. R. Steele , M. Micha-Screttas, E. Levin, N. G. Lemcoff, Tetrahedron, 2013, 69,  3885-3895; “Synthesis, characterisation, electronic spectra and electrochemical investigation of ferrocenyl-terminated dendrimers”

G. Cravotto, K. Martina, M. Caporaso, G. Heropoulos, L. Jicsinszky, 2012 MRS Fall Meeting, Boston 25-30 Nov. 2012, MRS Online Proceedings Library, 2013,1492,177-182; “Highly efficient Synthesis of per-substituted amino-cyclodextrins under Microwave Irradiation in a closed Cavity”

K. Martina, G. Cravotto, M. Caporaso, L. Rinaldi, C. Villalonga-Barber, G. Ermondi, Org. Biomol. Chem. 2013, 11, 5521-5527; “Efficient microwave-assisted synthetic protocols and in silico behaviour prediction of per-substituted beta-cyclodextrins”



C. G. Screttas, B. R. Steele, M. Micha-Screttas, G. A. Heropoulos, Org. Lett., 2012, 14,5680–5683; “Aryllithiums with Increasing Steric Crowding and Lipophilicity Prepared from Chlorides in Diethyl Ether. The First Directly Prepared Room-Temperature-Stable Dilithioarenes”

K. Gardikis, M. Micha-Screttas, C. Demetzos, B. R. Steele, Curr. Med. Chem. 2012, 19, 4913-4928;“Dendrimers and the development of new complex nanomaterials for biomedical applications”

R. Csonka, C. Villalonga-Barber, V. Psycharis, C. P. Raptopoulou, B.R. Steele, Polyhedron, 2012, 34, 181-187; “Transition metal complexes of new glyoxylatoaroylhydrazonesand their role in L-ascorbic acid oxidation inhibition”

H. Oberacher, F. Pitterl, E. Siapi, B. R. Steele, T. Letzel, S. Grosse, B. Poschner, F. Tagliaro, R. Gottardo, S. A. Chacko, J. L. Josephs, J. Mass Spectrom. 2012, 47, 263-270; “On the inter-instrument and the inter-laboratory transferability of a tandem mass spectral reference library. 3. Focus on ion trap and up-front CID”



C. Villalonga-Barber, A. K. Meligova, X. Alexi, B. R. Steele, C. E. Kouzinos, C. G. Screttas, E. S. Katsanou, M. Micha-Screttas, M. N. Alexis, Bioorg. Med. Chem. 2011, 19, 339-351; "New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription"

C. Koukoulitsa, S. Durdagi, E. Siapi, C. Villalonga-Barber, X. Alexi, B. R. Steele, M. Micha-Screttas, M. N. Alexis, T. Mavromoustakos, Eur. Biophys. J. 2011, 40, 865–875; “Comparison of themal effects of stilbenoid analogs in lipid bilayers using differential scanning calorimetry and molecular dynamics. Correlation of their thermal effects and topographical position with antioxidant activity”

G. A. Heropoulos, C. Villalonga-Barber, Tetrahedron Lett., 2011, 52, 5319–5322; “A clean, palladium-catalyzed oxidative esterification of aldehydes using benzyl chloride”

K. Martina, M. Caporaso, S. Tagliapietra, G. Heropoulos, O. Rosati, G. Cravotto, Carbohydr. Res., 2011, 346, (17), 2677-2682;“Synthesis of water-soluble multidentate aminoalcohol β-cyclodextrin derivatives via epoxide opening”

G. A. Heropoulos, (Guest Editor), Special issue of Current Organic Chemistry , 2011, 15, (2), 149-150; “Organic Chemistry with Microwaves and Ultrasound”

C. Stangel, G. Charalambidis, V. Varda, A.G. Coutsolelos, I.D. Kostas, Eur. J. Inorg. Chem. 2011, (30), 4709-4716; “Aqueous–Organic Biphasic Hydrogenation of trans-Cinnamaldehyde Catalyzed by Rhodium and Ruthenium Phosphane-Free Porphyrin Complexes”



K. Gardikis, S. Hatziantoniou, M. Bucos, D. Fessas, M. Signorelli, T. Felekis, M. Zervou, C. G. Screttas, B. R. Steele, M. Ionov, M. Micha-Screttas, B. Klajnert, M. Bryszewska, C. Demetzos, J. Pharm. Sci. 2010, 99, 3561-3571; “New Drug Delivery Nanosystem Combining Liposomal and Dendrimeric Technology (Liposomal Locked-In Dendrimers) for Cancer Therapy”

M. Bucos, C. Villalonga-Barber, M. Micha-Screttas, B. R. Steele, C. G. Screttas, G. A. Heropoulos, Tetrahedron, 2010, 66, 2061-2065. “Microwave assisted solid additive effects in simple dry chlorination reactions with N- chlorosuccinimide”

K. Gardikis, S. Hatziantoniou, M. Signorelli, M. Pusceddu, M. Micha-Screttas, A. Schiraldi, C. Demetzos, D. Fessas, Colloids Surf. B: Biointerfaces, 2010, 81, 11-19. “Thermodynamic and structural characterization of Liposomal-Locked in-Dendrimers as  drug carriers”

K. Gardikis, C. Tsimplouli, K. Dimas, M. Micha-Screttas , C. Demetzos, Int. J. Pharm. 2010, 402, 231-237. “New chimeric advanced Drug Delivery nanosystems (chi-aDDnSs) as Doxorubicin carriers”

K.-M. Alexacou, A.-C. Tenchiu (Deleanu), E. D. Chrysina, M.-D. Charavgi, I. D. Kostas, S. E. Zografos, N. G. Oikonomakos, D.D. Leonidas, Bioorg. Med. Chem. 2010, 18 (22), 7911-7922; “The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors”

D. M. Hodgson, C. Villalonga-Barber, J. M. Goodman, S. C. Pellegrinet, Org. Biomol. Chem. 2010, 8, 3975-3984; “Synthetic and computational studies on the tricarboxylate core of 6,7-dideoxysqualestatin H5 involving a carbonyl ylide cycloaddition-rearrangement”



S. Aime, E. Gianolio, F. Arena, A. Barge, K. Martina, G. A. Heropoulos and G. Cravotto, Org. Biomol. Chem., 2009, 7, (2), 370-379;“New cyclodextrin dimers and trimers capable of forming supramolecular adducts with shape-specific ligands”

A.-C. Tenchiu (Deleanu), I. D. Kostas, D. Kovala-Demertzi, A. Terzis, Carbohydr. Res. 2009, 344 (11), 1352-1364; “Synthesis and characterization of new aromatic aldehyde/ketone 4-(β-D-glucopyranosyl)thiosemicarbazones”

I. D. Kostas, F. J. Andreadaki, E. A. Medlycott, G. S. Hanan, E. Monflier, Tetrahedron Lett. 2009, 50 (16), 1851-1854; “Synthesis of a halo-methylphenylene periphery-functionalized triazine-based dendritic molecule with a 3,3´-dimethyl-biphenyl linker using tris(halo-methylphenylene)triazines as building blocks”



I. D. Kostas, Curr. Org. Synth. 2008, 5 (3), 227-249; “Recent Advances on P,N-Containing Ligands for Transition-Metal Homogeneous Catalysis”

D. Kovala-Demertzi, N. Kourkoumelis, K. Derlat, J. Michalak, F. J. Andreadaki, I. D. Kostas, Inorg. Chim. Acta 2008, 361 (5), 1562-1565; “Thiosemicarbazone-derivatised palladium nanoparticles as efficient catalyst for the Suzuki-Miyaura cross-coupling of aryl bromides with phenylboronic acid”

I. D. Kostas, K. A. Vallianatou, J. Holz, A. Börner, Tetrahedron Lett. 2008, 49 (2), 331-334; “A new easily accessible chiral phosphite-phosphoramidite ligand based on 2-anilinoethanol and R-BINOL moieties for Rh-catalyzed asymmetric olefin hydrogenation”

M. Micha-Screttas, H. Ringsdorf, Curr. Top. Med. Chem, 2008, 8, 1161-1164; “Polymer Science and Polymer Therapeutics: Macromolecules, Dendrimers and Nanomedicine”

C. Villalonga-Barber, M. Micha-Screttas, B. R. Steele, A. Georgopoulos, C. Demetzos, Curr. Top. Med. Chem, 2008, 8, 1294-1309; “Dendrimers as Biopharmaceuticals: Synthesis and Properties”

F. Wiesbrock, C. Patteux, T. K. Olszewski, A. Blanrue, G. A. Heropoulos, B. R. Steele, M. Micha-Screttas, T. Calogeropoulou, Eur. J. Org. Chem. 2008, 4344-4349; “Solution-Phase Synthesis and Scale-Up of 1st Generation Tetraester-Dendritic Branches Involving Microwave Irradiation and/or Ultrasound”

S. V. Amosova, V. N. Elokhina, A. S. Nakhmanovich, L. I. Larina, A. V. Martynov, B. R.Steele, V. A. Potapov, Tetrahedron Lett. 2008, 49, 974-976; Reactions of selenoureawith benzoyl- and 2-thienoylbromo-acetylenes: synthesis of 1,3-diselenetanes and 1,4-diselenafulvenes”

S. K. Mastronicolis, N. Arvanitis, A. Karaliota, P. Magiatis, G. A. Heropoulos, C. Litos, H. Moustaka, A. Tsakirakis, E. Paramera, P. Papastavrou, Appl. Envir. Microbiol., 2008, 74, 4543-4549; “Coordinated Regulation of Cold-Induced Changes in Fatty Acids with Cardiolipin and Phosphatidylglycerol Composition among Phospholipid Species for the Food Pathogen Listeria monocytogenes”



G. Skretas, A. Meligova, C. Villalonga-Barber, D. J. Mitsiou, M. N. Alexis, M. Micha-Screttas, B. R. Steele, C. G. Screttas, D. W. Wood, J. Am. Chem. Soc. 2007, 129, 8443 – 8457; “Engineered chimeric enzymes as tools for drug discovery: Generating reliable bacterial screens for the detection, discovery and assessment of estrogen receptor modulators”

B. R. Steele, G. A. Heropoulos, C. G. Screttas, Collect. Czech. Chem. Commun. 2007, 72, 589-598; “Metal chloride reductions with aromatic radical anions. The magnesium chloride catalysed cleavage of tetrahydrofuran by sodium naphthalene radical anion”

B. R. Steele, S. Georgakopoulos, M. Micha-Screttas, C. G. Screttas, Eur. J. Org. Chem. 2007, 3091-3094; “Synthesis of new sterically hindered anilines”

G. Pagona, A. S. D. Sandanayaka, A. Maigne, J. Fan, G. C. Papavassiliou, I. D. Petsalakis, B. R. Steele, M. Yudasaka, S. Iijima, N. Tagmatarchis, O.Ito, Chem. Eur. J. 2007, 13, 7600-7607; “Photo-induced electron-transfer on aqueous carbon nanohornpyrene-tetrathiafulvalene architectures”

G. C. Papavassiliou, G. C. Anyfantis, B. R. Steele, A. Terzis, C. P. Raptopoulou, G. Tatakis, G. Chaidogiannos, N. Glezos, Y. Weng, H. Yoshino, K. Murata, Z. Naturforsch. B, 2007, 62b, 679-684; “Some new nickel 1,2-dichalcogenolene complexesas single-component semiconductors”

G. A. Heropoulos, G. Cravotto, C. G. Screttas, B. R. Steele, Tetrahedron Lett. 2007, 48, 3247-3250; “Contrasting chemoselectivities in the ultrasound and microwave assisted bromination reactions of substituted alkylaromatics with N-bromosuccinimide”

I. D. Kostas, A. G. Coutsolelos, G. Charalambidis, A. Skondra, Tetrahedron Lett. 2007, 48 (38), 6688-6691; “The first use of porphyrins as catalysts in cross-coupling reactions: a water-soluble palladium complex with a porphyrin ligand as an efficient catalyst precursor or the Suzuki–Miyaura reaction in aqueous media under aerobic conditions”

K. A. Chatziapostolou, K. A. Vallianatou, A. Grigoropoulos, C. P. Raptopoulou, A. Terzis, I. D. Kostas, P. Kyritsis, G. Pneumatikakis, J. Organomet. Chem. 2007, 692 (19), 4129-4138; “Synthesis and characterization of new RhI complexes bearing CO, PPh3 and chelating P,O- or Se,Se-ligands. Application to hydroformylation of styrene”



K. A. Vallianatou, I.D. Kostas, J. Holz, A. Börner Tetrahedron Lett. 2006, 47 (45), 7947-7950; “Me-AnilaPhos: A new chiral phosphine–phosphoramidite ligand for a highly efficient Rh-catalyzed asymmetric olefin hydrogenation”

I. D. Kostas, B. R. Steele, A. Terzis, S. V. Amosova, A. V. Martynov, N. A. Makhaeva Eur. J. Inorg. Chem. 2006, (13), 2642-2646; “New Palladium Complexes with S- or Se-Containing Schiff-Base Ligands as Efficient Catalysts for the Suzuki-Miyaura Cross-Coupling Reaction of Aryl Bromides with Phenylboronic Acid under Aerobic Conditions”

I. D. Kostas, G. A. Heropoulos, D. Kovala-Demertzi, P. N. Yadav, J. P. Jasinski, M. A. Demertzis, F. J. Andreadaki, G. Vo-Thanh, A. Petit, A. Loupy Tetrahedron Lett. 2006, 47 (26), 4403-4407; “Microwave-promoted Suzuki-Miyaura cross-coupling of aryl halides with phenylboronic acid under aerobic conditions catalyzed by a new palladium complex with a thiosemicarbazone ligand”

E.I. Tolis, K.A. Vallianatou, F.J. Andreadaki, I.D. Kostas Appl. Organomet. Chem. 2006, 20(5), 335-337 “A new rhodium complex with a nitrogen-containing bis(phosphine oxide) ligand as an efficient catalyst for the hydroformylation of styrene”

B. R. Steele, C. Villalonga-Barber, M. Micha-Screttas, C. G. Screttas, Tetrahedron Lett. 2006, 47, 2093-2097; “Selective catalytic carbanionic ethylation of methylphenols: influence of catalyst and substitution pattern”

C. Villalonga-Barber, B. R. Steele, V. Kovač, M. Micha-Screttas, C. G. Screttas, J. Organomet. Chem. 2006, 691, 2785-92; “New stable, isolable triarylmethyl based dyes absorbing in the near infrared”

K. Gardikis, M. Micha-Screttas, B. R. Steele, C. Demetzos, Pharmakeftiki, 2006, 19, IV, 89-92; “An Overview of Dendrimers and their Biomedical Applications”
S. K, Mastronicolis, A. Boura, A. Karaliota, P. Magiatis, N. Arvanitis, C. Litos, A. Tsakirakis, P. Paraskevas, H. Moustaka and G. A. Heropoulos, Food Microbiol., 2006, 23,  184–194; “Effect of cold temperature on the composition of different lipid classes of the foodborne pathogen Listeria monocytogenes: Focus on neutral lipids”

G. Cravotto, L. Boffa, M. Bia, W. Bonrath, M. Curini and G. A. Heropoulos, Syn. Lett., 2006,2605-2609; “An Easy Access to Aromatic Azo Compounds under Ultrasound/Microwave Irradiation”



C. G. Screttas, G. A. Heropoulos, M. Micha-Screttas, B. R. Steele, Tetrahedron Lett. 2005, 46, 4357-4360; “Medium-dependent lithiated side products in the reductive lithiation of allylic phenyl thioethers. Diethyl ether versus tetrahydrofuran”

C. Arbez-Gindre, B. R. Steele, G. A. Heropoulos, C. G. Screttas, J.-E. Communal, W. J. Blau, I. Ledoux-Rak, J. Organomet. Chem. 2005, 690, 1620-1626; “A facile organolithiumroute to ferrocene-based triarylmethyl dyes with substantial near IR and NLO properties”

G. A. Heropoulos, S. Georgakopoulos and B. R. Steele, Tetrahedron Lett. 2005, 46, (14), 2469-2473; “High intensity ultrasound-assisted reduction of sterically demanding nitroaromatics”

S. Mastronicolis, N. Arvanitis, A. Karaliota, C. Litos, G. Stavroulakis, H. Moustaka, A. Tsakirakis and G. A. Heropoulos, Food Microbiol., 2005, 22 (2-3), 213-219; “Cold dependence of fatty acid profile of different lipid structures of Listeria monocytogenes”

S.V. Amosova, N. A. Makhaeva, A. V. Martynov, V. A. Potapov, B. R. Steele, I. D. Kostas, Synthesis, 2005, (10), 1641-1648; “Terminal organochalcogenoethyl- and -propylamines and their Schiff base derivatives”

N. G. Oikonomakos, M. N. Kosmopoulou, E. D. Chrysina, D. D. Leonidas, I. D. Kostas, K. U. Wendt, T. Klabunde, E. Defossa Protein Sci. 2005, 14 (7), 1760-1771; “Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs”

I. D. Kostas, K. A. Vallianatou, J. Holz, A. Börner Appl. Organomet. Chem. 2005, 19 (10), 1090-1095; “Rhodium complexes with a new chiral nitrogen-containing BINOL-based diphosphite or phosphonite ligand: synthesis and application to hydroformylation of styrene and/or hydrogenation of prochiral olefins”

N. V. Dubrovina, V. I. Tararov, A. Monsees, A. Spannenberg, I. D. Kostas, A. Börner Tetrahedron: Asymmetry 2005, 16 (22), 3640-3649; “New chiral 1,3-diphosphine ligands for Rh-catalyzed enantioselective hydrogenation: a search for electronic effects”

I. D. Kostas, F. J. Andreadaki, D. Kovala-Demertzi, C. Prentjas, M. A. Demertzis Tetrahedron Lett. 2005, 46 (12), 1967-1970; “Suzuki-Miyaura cross-coupling reaction of aryl bromides and chlorides with phenylboronic acid under aerobic conditions catalyzed by palladium complexes with thiosemicarbazone ligands”


Book Chapters

I.D. Kostas, “Recent Advances in P,N-Containing Ligands for Transition-Metal Homogeneous Catalysis”. In Advances in Organic Synthesis, Atta-ur-Rahman, FRS (Ed.), Bentham Science, 2013, Vol. 6, pp. 3-58. Invited book chapter.

I.D. Kostas, “Other P/N-Ligands”. In Phosphorus Ligands in Asymmetric Catalysis – Synthesis and Applications, A. Börner (Ed.), Wiley-VCH, Weinheim, 2008, vol. 2, part IV, chapter 1.2, pp. 596-632. Invited book chapter.

N.G. Oikonomakos, M.N. Kosmopoulou, D.D. Leonidas, E.D. Chrysina, C. Tiraidis, N. Bischler, K.E. Tsitsanou, S.E. Zographos, I.D. Kostas, G. Eisenbrand, “Indirubin and indigo analogues as potential inhibitors of glycogenolysis: structural basis of glycogen phosphorylase inhibition”. In Indirubin, the red shape of indigo, L. Meijer, N. Guyard, L. A. Skaltsounis, G. Eisenbrand (eds.). Editions “Life in Progress”, Roscoff, 2006, Chapter 18, 177-189.



GR:1005435: “New substituted stilbenoid derivatives with neuroprotective activity” M. Micha-Screttas, C. Villalonga Barber, B. R. Steele, M. N. Alexis.2006






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