Grant Award to Dr Fotis Kyrilis for CRYOMACRO project, within the framework of the 4th Call for H.F.R.I. Research Projects to support Postdoctoral Researchers

Dr. Fotis Kyrilis, Post Doctoral Associate of ICB and member of the ERA Chair Hot4Cryo project team has been awarded funding through the 4th Call for H.F.R.I. Research Projects supporting Postdoctoral Researchers, for the project “Integrative structural investigation of macroH2A nucleosomes and definition of the mechanistic insights that involve them in altering transcription profiles”, with a total budget of €99,437, starting in April 2026.

The project focuses on understanding how the histone variant macroH2A1.1 influences chromatin structure and gene expression regulation. By combining cryo-electron microscopy (cryo-EM) with crosslinking mass spectrometry (XL-MS) and large-scale sequencing data, the study aims to uncover how nucleosome composition and transcription factors shape transcriptional outcomes.

The research will be conducted at the newly established cryo-EM facility at NHRF, contributing to the structural characterization of chromatin and advancing interdisciplinary research at the interface of biochemistry, and structural biology.