Νόμοι ερεθίσματος-αντίληψης-αντίδρασης κυττάρων

Nanoscale stimulus-perception reaction of cells elucidates bio-memory at different hierarchies and adaption and viability at extreme environmental conditions.

The unusual high cell viability at extreme environmental conditions is deciphered by applying novel mathematical models of complexity and hierarchy and also experimental approaches (Nano-indentation, Raman spectroscopies, DNA electrophoresis). Cell’s viscoelastic and noise signatures are exposed by measuring and evaluating the scaling exponents of relaxation functions and the power spectral densities. The novel methodologies exploit nano-resolution of force-time derivatives and demonstrate bio-memory in cells under harmful external stressing. The results elucidate the notable high viability of fungal cells under harsh Space conditions, including exposure to Solar radiation (VUV), low and high vacuum and temperature, and the high resistivity of cancer cells to chemotherapy.

Key Publications

J. Phys. Chem. B  2021, 125, 10883

J. Appl. Phys. 2014, 116, 104701