ADME-Tox

Pharmacokinetic properties, Absorption, Distribution, Metabolism, Excretion (ADME), and the toxicity of xenobiotics are critical factors in decision-making for pharmaceutical R&D and planetary health challenges. Our IN3 framework offers comprehensive ADME-Tox services spanning in silico, in vitro, and in vivo approaches, backed by long-standing expertise in the field. Our broad capabilities and flexible mindset enable us to adapt to a wide range of project requirements, from fit-for-purpose exploratory studies to full regulatory compliance. We pride ourselves on delivering state-of-the-art service quality with a personalised approach for each project, designing and executing ADME-Tox services per relevant regulatory guidelines and recommendations.

We serve both industry and academia, B2B and B2C, through our agile IN3 innovation framework. By integrating computational and experimental methods in a single tri-modal platform, we fast-track safe, effective therapeutics, advanced materials, and smart systems from concept to society. Our mission-driven work contributes to global health and innovation, aligning with the United Nations Sustainable Development Goals (SDGs), notably SDG 3: Good Health & Well-Being and SDG 9: Industry, Innovation & Infrastructure, to promote better health outcomes and foster sustainable innovation.

Our Services

We offer a wide range of ADME-Tox services (in silico, in vitro, in vivo) supported by expert
consulting and data analysis.

Key offerings include:

• In silico ADME-Tox: Advanced computational modelling and data analysis, including pharmacokinetic/ pharmacogenomic analyses, molecular pathway analysis, population PK modelling, PK/PD simulations, and physiology-based pharmacokinetic modelling.
• In vitro ADME-Tox: Laboratory assays to determine metabolic stability, enzyme interactions (CYP450 inhibition assays), xenobiotic interaction effects, plasma protein binding, membrane permeability (e.g. blood-brain barrier, skin, gastrointestinal tract models), cardiotoxicity (hERG assays), and overall toxicity profiling.
• In vivo ADME-Tox: In vivo pharmacokinetic and toxicokinetic studies in relevant models to observe the absorption, distribution, metabolism, excretion, and toxicity of xenobiotics in a whole organism.
• Consulting Services: Expert advisory services on experimental design, regulatory strategy, and project planning to optimise your R&D pipeline.
• Data Analysis and Interpretation: Comprehensive analysis of experimental data with clear, actionable reports. Our experts interpret the ADME-Tox results to provide insights and recommendations for your compound or product.

How It Works

Step 1: Request & Consultation

Contact us to discuss your ADME-Tox needs. Our experts will consult with you to design a study plan tailored to your objectives and in line with regulatory guidelines.

Step 2: Sample Submission

Fill out the ADME-Tox Service Request Form and send it along with your samples (upon assigning a unique code to each sample, ensuring compliant handling and confidentiality). If needed, a Material Transfer Agreement (MTA) and/or a Non Disclosure Agreement (NDA) shall be put in place prior to any action.

Step 3: Analysis & Testing

Our scientists conduct the agreed in silico, in vitro, and/or in vivo tests using state-of-the-art methods and infrastructure. We maintain rigorous quality control at every stage to ensure reliable, high-quality data.

Step 4: Reporting & Interpretation

After the analysis, we provide a detailed report of the results. Our team also offers expert interpretation of the data, explaining the ADME-Tox profile of your interest and its implications.

Step 5: Follow-Up & Support

We remain available for follow-up discussions, additional analyses, or further consulting as needed. Whether you require supplementary studies, method development, or regulatory advice, our team continues to support your innovation journey every step of the way.

Why Choose Us

• Integrated ADME-Tox Platform: We utilise a unique IN3 approach that fuses in silico, in vitro, and in vivo methodologies into one comprehensive framework for ADME-Tox profiling. This integration provides a complete and efficient evaluation of xenobiotics.
• Personalized & Flexible Service: Our offerings are tailored to your needs. We can design anything from early fit-for-purpose studies to fully compliant, regulatory-grade studies, ensuring a custom solution for every project. This flexible approach means you get exactly what is fit for purpose and can scale up to compliance as required.
• Quality & Regulatory Compliance: We adhere to international regulatory guidelines in all our studies. Our GLP-compliant mindset and rigorous protocols ensure that the data we generate is high-quality, reliable, and ready for regulatory submissions or audits.
• Expertise & Track Record: Our team has a proven track record of delivering ADME-Tox solutions. We have provided services to academic institutions and industry partners. We are equipped to tackle challenging projects and novel xenobiotics with confidence.
• End-to-End Support: We offer an end-to-end solution from initial study design and sample handling to data analysis and interpretation. Our “one-stop-shop” approach means you can rely on us for every step of the process, reducing complexity and ensuring consistent quality and communication throughout.
• Impact & Innovation: By design, our services contribute to a healthier, more innovative world. We aim to advance human health and planetary well-being through sustainable innovation. Our work supports international initiatives like the UN Sustainable Development Goals, especially Goal 3 (Good Health & Well-Being) and Goal 9 (Industry, Innovation & Infrastructure), ensuring that partnering with us means contributing to broader societal and environmental progress.