Curriculum Vitae

Maria Micha-Screttas, Research Director

Tel: +30 210 7273878
Fax: +30 210 7273877
E-mail: mskreta

Education

Diploma in Pharmacy, 1968 , University of Athens
PhD in Pharmaceutical Chemistry, 1972, University of Athens 

Employment

1972-1973 Researcher, NRCPS ''Demokritos''

1973 Researcher, National Hellenic Research Foundation

1985 (six months) Visiting researcher, Wayne State Univ. of Detroit, Michigan

2000-present Research Director, Institute of Organic and Pharmaceutical Chemistry 

July 2001-March 2003 Acting Director of the Institute of Organic and Pharmaceutical Chemistry

Fellowships

1968-1972 NRCPS, ''Demokritos'' for PhD studies

1964-1967 State fellowship (IKY) for undergraduate studies

Research Interests

Over 30 years experience in the field of Organic and Organometallic Chemistry and especially in the study of paramagnetic organometallic compounds and radical anions by multinuclear NMR. Current research interests are focused on the synthesis of :

- Organic-organometallic functional materials (e.g NIR-Dyes).
- Bioactive molecules
- Dendrimer chemistry
- Solid phase synthesis and high energy techniques

Funded Programmes

Coordinator and Scientist in Charge for the IOPC programme for the Center of Excellence Research programme with the title: ''Novel strategies Against Neurodegeneration''
2002-2005, (General Secretariat for Research and Technology) 200.000 €

Patent
Number Gr:1005435
Title: ''New substituted stilbenoid derivatives with neuroptotective activity''
M.Micha-Screttas, C. Villalonga Barber, B.R.Steele, M.N.Alexis

Participation in Joint Research Programmes

1. '' A European Research Training Site for the Design and Syntheis of Novel
Neuroprotective and Hypoglycaemic Agents through a Multi-disciplinary
approach (Acronym: EURODESY)''
MEST-CT-2005 Contract No.-020575 (1/2/2006-31/1/2010)

2. ''Solid Phase Phospholipid and Dendrimer Synthesis'' Marie Curie Host Fellowships for the Transfer of Knowledge (ToK) (1/2/2005-31/1/2009)

3. ''Design, Synthesis and Study of Novel Organometallic Near Infrared Dyes'' Marie Curie Intra-European Fellowships (1/2/2004-31/1/2006)

4. ''Synthesis of Compatible Organic Additives for the Protection of Coloured Polyester Fibres from Photochemical Bleaching'' Operational Programme for Research and Technology (EPET/YPER 97). A collaboration between the National Hellenic Research Foundation and VIOCHROM Ltd.

5. ''Design, Synthesis and Study of Novel Non-linear Optical Materials'' - Training and Mobility of Researchers Network (1/10/96-30/9/99)
The network was coordinated from the National Hellenic Research Foundation and comprised nine groups from Greece, UK, Ireland, France, Germany and Sweden.

6. ''Simple and Mixed Metal Alkyls, Alkoxides and Amides in Synthesis and Catalysis and as Precursors for Ceramic and Polymeric Materials'' - Human Capital and Mobility Network (1/12/93-31/3/97)
The network was coordinated from the National Hellenic Research Foundation and comprised nine groups from Greece, UK, Ireland, Spain, France, Germany, The Netherlands

7. ''Conjugated Ladder-Type Oligomers and Polymers Containing Fused Six- and Five- Membered Rings'' - Human Capital and Mobility Network (1/9/93-31/12/96)
The network comprised eight groups from the UK, Greece, Portugal, Italy and Germany.

Publications

Barry R. Steele, Carolina Villalonga-Barber, Maria Micha-Screttas and
Constantinos G. Screttas , Tetrahedron Lett. 2006, 47, 2093-2097
''Selective catalytic carbanionic ethylation of methylphenols: influence of
catalyst and substitution pattern''

Carolina Villalonga-Barber, Barry R. Steele, Veronica Kovac, Maria
Micha-Screttas and Constantinos G. Screttas , J.Organom. Chem. 2006, 691, 2785-92
''New stable, isolable triarylmethyl based dyes absorbing in the near infrared''

K.Gardikis, M.Micha-Screttas, B.Steele and C.Demetzos, Pharmaceftiki, 2006, 19, IV, 89-92, ''An Overview of Dendrimers and their biomedical Applications''

C.G. Screttas, G.A. Heropoulos, M. Micha-Screttas and B.R. Steele, Tetrahedron Lett. 2005, 46, 4357-4360
''Medium-dependent lithiated side products in the reductive lithiation of allylic phenyl thioethers. Diethyl ether versus tetrahydrofuran''

A. Lazaridou, C.G. Biliaderis, M. Micha-Screttas and B.R. Steele, Food Hydrocolloids, 2004, 18, 837-55
''A comparative study on structure – function relations of mixed linkage (1�3),(1�4) linear b-D-glucans''

B.R. Steele, M. Micha-Screttas and C.G. Screttas, Tetrahedron Lett. 2004, 45, 9537-9540. 
''Synthesis and properties of 1-bromo-2,3,5,6-tetrakis(3-pentyl)benzene : a highly sterically hindered aryl bromide'' 

D.P. Catsoulacos, B.R. Steele, G.A. Heropoulos, M. Micha-Screttas and C.G. Screttas, Tetrahedron Lett. 2003, 44, 4575-4578. 
''An iminophosphine dendrimeric ligand and its evaluation in the Heck reaction''

C.G. Screttas, G.A. Heropoulos, M. Micha-Screttas, B.R. Steele and D.P. Catsoulacos Tetrahedron Lett. 2003, 44, 5633-5635
''Reductive lithiation of alkyl phenyl sulfides in diethyl ether. A ready access to a,a-dialkylbenzyllithiums''

B.R. Steele, M. Micha-Screttas and C.G.Screttas Appl. Organometal. Chem. 2002, 16, 501-505
'' Applications of novel sterically demanding aromatics in organometallic synthesis'' 

M. Micha-Screttas, C.G. Screttas, B.R. Steele and G.A.Heropoulos Tetrahedron Lett. 2002, 43, 4871-4873
''Chemical and physical evidence for metal-metal interchange between lithium alkoxides and di-n-butylmagnesium''

M.Micha-Screttas, G.A. Heropoulos and B.R.Steele Mag. Res. Chem. 2001, 39, 586-592 ''Stability of alkali metal monosubstituted benzophenone radical anions with respect to solvent perturbations''

C.S. Salteris, I.D. Kostas, M.Micha-Screttas, G.A. Heropoulos, C.G. Screttas and A. Terzis J. Org. Chem. 1999, 64, 5589-5592
''ortho-Directed lithiation of w-phenoxyalcohols''

C.S. Salteris, I.D. Kostas, M. Micha-Screttas, G.A. Heropoulos, C.G. Screttas and A. Terzis Main Group Met. Chem. 1999, 22, 427-434 
''ortho-Directed lithiation of w-phenoxyalkanethiols and N,N-dimethyl, w-phenoxyalkaneamines. Crystal structure of bis[o[(dimethylamino) ethoxy]phenyl]mercury''

C.S. Salteris, I.D. Kostas, M.Micha-Screttas, B.R. Steele, G.A.Heropoulos, C.G. Screttas and A. Terzis J. Organomet. Chem. 1999, 590, 63-70
''Synthesis of lithium w-(m- and p-lithiophenoxy)alkoxides modified with magnesium 2-ethoxyethoxide. Crystal structures of bis [4-(2-hydroxyethoxy) phenyl]mercury and bis[4-(3-hydroxypropoxy)phenyl]mercury''

M. Micha-Screttas, G.A. Heropoulos and B.R. Steele J. Chem. Soc Perkin Transactions 2, 1999, 7, 1443-1446
''Evidence for a concentration dependent 6(7)Li NMR contact shift in tetrahydrofuran solutions of lithium naphthalene radical anion and the effect of added 6(7)LiCl''

M. Micha-Screttas, G.A. Heropoulos and B.R. Steele J. Chem. Soc Perkin Transactions 2, 1999, 12, 2685-2690
''Interaction between alkali metal aromatic ketone radical anions and the chlorides of lithium and magnesium in solution. A case of a carbon-carbon bond strengthening through complex formation''

A. Detsi, M. Micha-Screttas and O. Igglessi-Markopoulou , J. Chem. Soc. Perkin Trans. 1 1998, 2443
''Synthesis of N-alkoxycarbonyl-3-substituted tetramic acids and functionalized enols via C- acylation reactions of active methylene compounds with N-hydroxysuccinimide esters of N-alkoxycarbonyl-a-amino acids''

C.G. Screttas, M. Micha-Screttas and B.R. Steele J. Organomet. Chem. 1997, 536, 149-163
''The tert-butyl chloride-lithium naphtalene radical anion and tert-butyllithium- naphthalene systems. Mechanism of metallation''

C.G. Screttas, G.I. Ioannou and M. Micha-Screttas J. Organomet. Chem. 1996, 511, 217-225
''Stoichiometry of Protonation of Aromatic Hydrocarbon Radical Anions by Weak Proton Donors. A Marked Discrepancy Between the Number of Protons Used and those Incorporated into the Aromatic Structure''

C.G . Screttas and M. Micha-Screttas J. Org. Chem. 1991, 56, 1615 
''Some Properties and trends of enthalpies of vaporization and of Trouton's ratios of organic compounds. Correlation of enthalpies of vaporization and of enthalpies of formation with normal boiling points''

C.G. Screttas and M. Micha-Screttas Bull. Soc. Chim. Belg. 1991, 100, 199
''Spectroscopic electronegativities of halogens are transferable and additive parameters . Examples of correlations with thermochemical and nuclear magnetic resonance spectroscopic data''

Maria Micha- Screttas Mag. Res. Chem. 1990, 28, 952-955
''Spectroscopic electronegativities correlated with the 13C NMR shifts of metal ( Ia, II a, III a ) 2-ethoxyethoxides''

F.S. Varveri, J. Nikokavouras, A.E. Mantaka-Marketou and M. Micha-Screttas Monats. fur Chemie 1989, 120, 967-971 
''Synthesis of terminally substituted 9-alkylidene-10-methyl acridans''

C.G . Screttas and M. Micha-Screttas J. Org. Chem. 1989, 54, 5132
''Correlation of thermochemical data with gas-phase ionization potentials''

C.G. Screttas and M. Micha-Screttas J. Am. Chem. Soc. 1987, 109, 7574
'' Radical anions in hydrocarbon media. interaction between unsolvated and / or solvated radical anions and metal alkoxides. Evidence for cation - dependent clustering of ketyl anions at high concentrations''

C.G . Screttas and M. Micha-Screttas J. Organomet. Chem. 1986, 316, 1
''Hexane-soluble complexes of alkyl- and alkenyl -sodium compounds with magnesium alkoxides''

C.G. Screttas and M. Micha-Screttas J. Organomet. Chem. 1985 , 290, 1
''The diphenylmagnesium / alkali metal alkoxide system . hydrocarbon soluble organoalkali metal reagents''

C.G. Screttas and M. Micha-Screttas J. Organomet. Chem. 1985, 292, 325
''Preparation of solvated and/or unsolvated simple and mixed diarylmagnesiums''

C.G. Screttas and M. Micha-Screttas Organometallics 1984 , 3, 904
''Hydrocarbon - soluble organoalkali-metal reagents. preparation of alkyl derivatives''

C.G. Screttas and M. Micha-Screttas J. Org. Chem. 1983, 48, 153
''Paramagnetic solvent NMR shifts in radical anion solutions 2. Some cation dependent phenomena in concentrated solutions of aromatic hydrocarbon radical anions and dianions''

C.G. Screttas and M. Micha-Screttas J. Org. Chem. 1983, 48, 252
''Paramagnetic solvent NMR shifts in radical anion solutions 3. A kinetic method for measuring molar paramagnetic solvent shifts of unstable radical anions''

C.G. Screttas and M. Micha-Screttas J. Phys. Chem. 1983, 87, 3844
''Paramagnetic solvent NMR shifts in radical anion solutions 4. Carbon-13 contact shifts and mechanism of spin density and/or electron Transfer to substrate''

C.G. Screttas and M. Micha-Screttas J. Organomet. Chem. 1983, 252, 263
''Single-titration method for the determination of lithium naphthalenide in tetrahydrofuran''

C.G. Screttas, M. Micha-Screttas and C.T. Cazianis Tetrahedron Lett. 1983, 24, 3287
''The benzilic ester rearrangement. Evidence for a SET pathway in benzilic ester and/or acid rearrangement'' 

C.G. Screttas and M. Micha-Screttas, J. Org. Chem. 1982, 47, 3008 
''Synthesis of benzhydryl ethers by C-C forming reaction using benzydryl 2-chloroethyl. A method for attaching a protected 2- hydroethyl group to benzylic carbon'' 

C.G . Screttas and M. Micha-Screttas J. C. S. Chem. Commun. 1982, 1168
''Carbon -13 contact solvent shifts in radical anion solutions. Mechanism of spin density transfer to solvent'' 

C.G. Screttas and M. Micha-Screttas, J. Org. Chem. 1981, 46, 993
''Structure of radical anions in solution as deduced from paramagnetic solvent shifts as molecular parameters for understanding structure, reactivity and solute-solvent interactions in ketyl anion solutions''

C.G. Screttas and M. Micha-Screttas, J. Org. Chem. 1979, 44, 713
''Markownikoff two-step hydrolithiation of a-olefins.transformation of secondary and tertiary alkyl phenyl sulfides to alkyllithium reagents''

C.G. Screttas and M.Micha-Screttas, J. Org. Chem. 1978, 43, 1064
''Hydrolithiation of a-olefins by regiospecific two-step process.transformation of alkyl phenyl sulfides to alkyllithium reagents''.

M. Micha-Screttas and C.G. Screttas, J. Org. Chem. 1977, 42, 1462
''Preparation of alkyl phenyl sulfides by electrophilically catalysed displacement of certain nucleophiles by thiophenoxy group''