Curriculum Vitae

ZERVOU Maria
Special Functional Scientist C'

Tel: +30 210 72 73 872
Fax: +30 210 72 73 831
E-mail: ezervou

Education

Ph.D. Chemistry, University of Patras, 2002.
M.Sc. Electronic Engineering, Department of Physics, University of Athens, 1992.
B.Sc. Physics, University of Athens, 1989.

Employment

1992-2003: Special Technical Scientist
Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation

2003-present: Special Functional Scientist C'
Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation

Responsible for the reliable operation of the two NMR spectrometers of the Institute, AC - 300 and MSL - 400 MHz for liquid and solid phase samples. Acquisition and processing of 1D- and 2D- experiments in liquid and solid phase.

Research Activities

• Conformational analysis of bioactive peptidomimetic molecules using Nuclear
  Magnetic Resonance''. Use of 1D and 2D NMR experiments in combination with Molecular Graphics in order to specify the bioactive conformation of antihypertensive drugs.
• Design and development of a new software to support the complicated
  certification process of Reference Materials through the recording and statistical processing of the laboratory measurements. The final version is freely distributed through NHRF's website: http://www.eie.gr/iopc/softcrm/index.html
• Study of the authenticity of food or beverage products as virgin olive oil or traditional spirits using Nuclear Magnetic Resonance.
  

Recent Publications

1. Nikolas-P. Benetis, Ioanna Kyrikou, Thomas Mavromoustakos, Maria Zervou. Static
   31P CP NMR Multilamellar Bilayer Broadlines in the Absence and presence of the Bioactive Dipeptide beta-Ala-Tyr and Comparison with Glu''. Chem. Phys. 314(1-3) 57-72 (2005).
2. P. Petrakis, I.Touris , M. Liouni, M. Zervou, I. Kyrikou, R. Kokkinofta, C. R.
   Theocharis, T.M. Mavromoustakos. Authenticity of the traditional Cypriot spirit ''Zivania'' on the basis of 1H NMR Spectroscopy Diagnostic Parameters and Statistical Analysis. J Agric Food Chem 53, 5293-5303 (2005)
3. A. Kapou, M. A. Fousteris, S. S. Nikolaropoulos, M.Zervou, S. G. Grdadolnik,
   P.Zoumpoulakis, I. Kyrikou, T. Mavromoustakos. 2D NMR and conformational analysis of a prototype anti-tumour steroidal ester. J. Pharm. Biomed. Anal. 38 (3), 428-434. (2005)
4. Dimitra Kovala-Demertzi, Vaso N. Dokorou, Jerry P. Jasinsky, Adam Opolski, Joanna Wiecek, Maria Zervou, Mavroudis A. Demertzis. Organotin flufenamates: Synthesis, characterization and antiproliferative activity of organotin flufenamates. J. Organ. Chem. 690, 1800-1806 (2005)
5. T. Mavromoustakos, P. Zoumpoulakis, I. Kyrikou, A. Zoga, E. Siapi, M. Zervou, I.
   Daliani, D. Dimitriou, A. Pitsas, C. Kamoutsis, P. Laggner. Efforts to Understand the Molecular Basis of Hypertension Trough Drug:Membrane Interactions. Curr Top Med Chem, 4, 445-459. (2004).
6. T. Mavromoustakos, M. Zervou, P. Zoumpoulakis, I. Kyrikou, N.P. Benetis, L. Polevaya, P. Roumelioti, N. Giatas, A. Zoga, P. Moutevelis Minakakis, A. Kolocouris, D. Vlahakos, S. Golic Grdadolnik, J. Matsoukas. Conformation and Bioactivity. Design and Discovery of Novel Antihypertensive Drugs. Curr Top Medl Chem, 4, 485-401. (2004).
7. T. Mavromoustakos, A. Kapou, N.P. Benetis, M. Zervou. Conformational Analysis Using 2D NMR Spectroscopy Coupled with Computational Analysis as an Aid in the Alignment Procedure of 3D-QSAR studies. Drug Design Reviews - Online, 1(3), 235-245(11). (2004).
8. P. Zoumpoulakis, I. Daliani, M. Zervou, I. Kyrikou, G. Lamprinidis, E. Mikros, T. Mavromoustakos. Losartan's Molecular Basis of Interaction with Membranes and AT1 Receptor. Chem. Phys. Lipids 125, 13-25. (2003)
9. G. Bonas, M. Zervou, A. Papaioannou and M. Lees. ''SoftCRM'': A new Software for the Certification of Reference Materials. Accredit Qual Assur, 8:101-107 (2003).
10. P. Zoumpoulakis, I. Daliani, M. Zervou, I. Kyrikou, G. Lamprinidis, E. Mikros, T. Mavromoustakos Losartan's molecular basis of interaction with membranes and AT1 receptor. Chem. Phys. Lipids 125, 13-25. (2003)
11. T. Mavromoustakos, M. Zervou, G. Bonas, A. Kolocouris, P. Petrakis. A Novel Analytical Method To Detect Adulteration of Virgin Olive Oil by Other Oils. J Am Oil Chem Soc 77(4) 405-411. (2000)

Patent

''A new method to detect adulteration of Virgin Olive Oil'' (No 1002879).
T. Mavromoustakos, G. Bonas, M. Zervou, E. Theodoropoulou.

Participation in funded programs

''The European Virtual Institute for Reference Materials'' (VIRM) (2002-2006). GROWTH (G7RT-CT-2002-05104)
Within this program National Hellenic Research Foundation is the National Contact Point.

"Production of new antihypertensive drugs'' (2003-2005)
02 PRAXE 173. Funded by the General Secretariat of Research & Technology.

''Authenticity of Cypriot beverage Zivania.'' (2003-2005)
Scientific and Technological Collaboration with the University of Cyprus 91/5th PΕ-2002.

''Development and Assessment of Methods for the Detection of Adulteration of Olive Oil with Hazelnut oil ''. GROWTH. Funded by EC. (2001-2003).

''Development of a new software for Certified Reference Materials through the wine and ethanols CRMs''. Standards Measurements and Testing program. Funded by EC. (1999-2001).

''Conformational analysis of pharmaceutical molecules and study of their interactions with membranes''. Joint Research and Technology Program between Slovenia and Greece (1999-2001). Funded by the General Secretariat of Research & Technology.

''A new integrated approach to the authentication of olive oil to improve its competitivity on the world market''. GROWTH-AIR2. Funded by EC. (1995-1998).

Thematic Network FIT-Food Analysis using Isotopic Techniques. Standards Measurements and Testing Programme. Funded by EC. (1996-1999).