IOPC - Curriculum Vitae

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Curriculum Vitae

Dr. Panagiotis g. Zoumpoulakis

Laboratory of Molecular Analysis,
Institute of Organic and Pharmaceutical Chemistry,
National Hellenic Research Foundation,
48 Vas. Constantinou Ave. 11635, Athens - Greece.
Tel. +30210-7273869, Fax: +30210-7273872
pzoump

CHEMIST-POST DOCTORAL FELLOW

Education

Ph.D.	2004, University of Patras, Dept. of Chemistry, Patras, Greece Supervisor: Prof. J. Matsoukas; Thesis Title: ''Use of NMR, x-Ray and Molecular Graphics for the conformational study of AT1 Antagonists and their Interactions with Biological Membranes and AT1 Receptor''
B.A	1999, Department of Chemistry, University of Patras, Patras, Greece

Employment
Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation
July 2001-July 2003 PhD Student
& April 2005-now Post Doctoral Fellow

Educational activities

1.9.2003 - 31.8.2004 NMR Spectroscopic Techniques on graduate students.
Department of Chemistry, University of Ioannina, Greece

Foreign Languages: English, Italian

Current Research Activities

Conformational Analysis and Molecular Modeling of Novel Antihypertensive Molecules.
Use of HR-NMR in combination with molecular graphics algorithms for determination of drug conformations in different solutions. This approach is applied to several AT1 antagonists already approved for the control of hypertension as well as novel synthetic ones. This activity leads to putative bioactive conformations of drug molecules at the binding site of the receptor.

Theoretical Docking Studies

Rational design is partially based on drug-receptor interactions. The scope of this analysis is the comprehension of the physicochemical parameters which determine interactions between the ligand and the active site. Computer programs dedicated to docking small molecules into protein binding pockets in silico are currently applied. This aids to the design of novel analogs which will possess the pharmacophoric segments suitable for specific interactions with the receptor.

Recent Publications (2003-2004)

Conformation and Bioactivity. Design and Discovery of Novel Antihypertensive Drugs.
	T. Mavromoustakos, M. Zervou, P. Zoumpoulakis, I. Kyrikou, N.P. Benetis, L. Polevaya, P. Roumelioti, N. Giatas, A. Zoga, P. Moutevelis Minakakis, A. Kolocouris, D. Vlahakos, S.G. Grdadolnik, J. Matsoukas. Current Topics in Medicinal Chemistry. 4, (2004), 385.
Efforts to Understand the Molecular Basis of Hypertension Through Drug: Membrane
	Interactions. T. Mavromoustakos, P. Zoumpoulakis, I. Kyrikou, A. Zoga, E. Siapi, M. Zervou, I. Daliani, D. Dimitriou, A. Pitsas, C. Kamoutsis, P. Laggner. Current Topics in Medicinal Chemistry. 4, (2004), 445.
Losartan's molecular basis of interaction with membranes and AT1 receptor.
	P. Zoumpoulakis, I. Daliani, M. Zervou, , I. Kyrikou, G. Lamprinidis, E. Mikros, T. Mavromoustakos. Chemistry and Physics of Lipids. 125, (2003), 13
Design and Synthesis of Novel Antihypertensive Drugs,
	P. Moutevelis-Minakakis, M. Gianni, H. Stougiannou, P. Zoumpoulakis, A. Zoga, A.D. Vlahakos, T. Mavromoustakos. Bioorganic and Medicinal Chemistry Letters. 13, (2003), 1737.
Conformational and biological studies for a pair of novel synthetic AT1 antagonists:
	stereoelectronic requirements for antihypertensive efficacy. P. Zoumpoulakis, A.Zoga, P. Roumelioti, N. Giatas, S.G. Grdadonlik, E. Iliodromitis, D. Vlahakos, D. Kremastinos, J.M. Matsoukas, T. Mavromoustakos. Journal of Pharmaceutical and Biomedical Analysis. 31, (2003) 833-844.

News

Highlights

	SOPHOLIDES Solid Phase Phospholipid and Dendrimer Synthesis Visit the webpage
	SUPRAGENE SUPRAmolecular chemistry and GENE transfer by dendrimers Visit the web page
	EURODESY A EUROPEAN EARLY STAGE research Training Site for Design AND synthesis Visit the web page
	The Institute of Organic and Pharmaceutical Chemistry is a memeber of the European Research Center for Drug Discovery and Development see more

Job Positions

	Two positions at the LMA laboratory for graduate and postgraduate theses
	Marie-Curie Research Fellowships for Transfer of knowledge project: "Supramolecular chemistry and gene therapeutic potential of amine-substituted cyclodextrin end-functionalized triazine dendrimers based on melamine'' (SUPRAGENE).
	Marie-Curie Research Fellowships for Transfer of knowledge project: "Supramolecular chemistry and gene therapeutic potential of amine-substituted cyclodextrin end-functionalized triazine dendrimers based on melamine'' (SUPRAGENE).
	MARIE CURIE RESEARCH FELLOWSHIPS in the framework of EURODESY project "A European Research Training Site for the Design and Synthesis of Novel Neuroprotective and Hypoglycaemic Agents through a Multi-disciplinary approach" (EURODESY)

Εvents

Design and synthesis of novel cardioprotective agents against ischemia/reperfusion injury
Research Director Dr. Maria Koufaki
01.04.2008

Events Archive

Last Update: 29.06.2005