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DRUGDESI

 

SCIENTIFIC PUBLICATIONS IN PEER-REVIEWED JOURNALS SUPPORTED BY DRUGDESI

2010

  1. Felfoldi, N., Toth, M., Chrysina, E.D., Charavgi, M-D., Alexacou, K-M., Somsak, L. (2010). Synthesis of new glycosyl biuret and urea derivatives as potential glycoenzyme inhibitors. Carbohydrate Res. 345, 208-213.

2009

  1. Chrysina, E.D., Bokor, E., Alexacou, K-M., Charavgi, M-D., Oikonomakos, G.N., Zographos, S.E., Leonidas, D.D., Oikonomakos, N.G., Somsak, L. (2009). Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case. Tetrahedron Asymm. 20, 733-740.
  2. Benltifa, M., Hayes, J.M., Vidal, S., Gueyrard, D., Goekjian, P.G., Praly, J-P*, Kizilis, G., Tiraidis, C., Alexacou, K-M., Chrysina, E.D.*, Zographos, S.E., Leonidas, D.D., Archontis, G. and Oikonomakos, N.G. (2009). Glucose-based Spiro-isoxazolines: A New Family of Potent Glycogen Phosphorylase Inhibitors. Bioorg. Med. Chem. 17, 7368-7380.
  3. Potamitis, C., Zervou, M., Katsiaris, V., Zoumpoulakis, P., Durdagi, D., Papadopoulos, M.G., Hayes, J.M., Gradolnik, S.G., Kyrikou, I., Argyropoulos, D., Vatougia, G., Mavromoustakos, T. (2009). Antihypertensive Drug Valsartan: Conformational Analysis, Dynamic NMR Spectroscopy, in silico Docking and Molecular Dynamics Studies. J. Chem. Inf. Mod. 49, 726-739.
  4. Dossi, K., Tsirkone, V.G., Hayes, J.M., Matousek, J., Pouckova, P., Soucek, J, Zadinova, M, Zographos, S.E., Leonidas, D.D.* (2009) Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors. Eur. J. Med. Chem. 44, 4496-4508.
  5. Zographos, S.E., Leonidas, D.D., Alexacou, K.M., Gimisis, T., Hayes, J.M., Oikonomakos, N.G.*, Wen, X., Sun, H., Liu, J., Cheng, K., Zhang, P., Zhang, L., Hao, J., Zhang, L., Ni, P. (2008) Pentacyclic Triterpenes Inhibitors of Glycogen Phosphorylase as Potential Drugs for Type 2 Diabetes: X-ray Crystallographic Studies, Planta Medica 74, 1146-1147.
  6. Somsak, L.*, Czifrak, K., Toth, M, Bokor, E., Chrysina, E.D., Alexacou, K-M, Hayes, J.M., Lazoura, E., Leonidas, D.D., Zographos, S.E., Oikonomakos, N.G.* (2008). New Inhibitors of Glycogen Phosphorylase as Potential Antidiabetic Agents. Current Medicinal Chemistry 15, 2933-2983.
  7. Wen, X., Sun, H., Liu, J., Cheng, K., Zhang, P., Zhang, L.Y., Hao, J., Zhang L.Y., Ni, P.Z., Zographos, S.E., Leonidas, D.D., Alexacou, K.M., Gimisis, T., Hayes, J.M., Oikonomakos, N.G* (2008). Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure-Activity Relationships and X-ray Crystallographic Studies", J. Med. Chem. 51, 3540-3544.
  8. Alexacou, K.M., Hayes, J.M., Tiraidis, C., Zographos, S.E., Leonidas, D.D., Chrysina, E.D., Archontis, G., Oikonomakos, N.G.*, Paul, J.V., Varghese, B., Loganathan D* (2008). Crystallographic and computational studies on 4-phenyl-N-(b-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: Comparison with a-D-glucose, N-acetyl-b-D-glucopyranosylamine and N-benzoyl-N-b-D-glucopyranosyl urea binding. Proteins: Structure, Function & Bioinformatics 71, 301-307.

Manuscripts in preparation

  1. Cismas, C., Hayes, J.M., Sovantzis, D., Hadjiloi, T., Mamais, M., Lazoura, E., Grammatopoulos, P., Stathis, D., Zographos, S.E., Leonidas, D.D., Oikonomakos, N.G., Gimisis, T., Chrysina, E.D. Synthesis, x-ray, and computational studies of b-D-glucose pyrimidine derivatives as glycogen phosphorylase inhibitors: the role of ligand ionization/tautomeric states examined.
  2. Nagy, V., Felfoldi, N., Praly, J-P., Docsa, T., Gergely, P., Chrysina, E.D., Tiraidis, C., Kosmopoulou, M., Alexacou, K.M., Konstantakaki, M., Leonidas, D.D., Zographos, S.E., Hayes, J.M., Oikonomakos, N.G., Somsak, L. N-(4-substituted-benzoyl)-N'-(b-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation.
  3. Chrysina, E.D., Nagy, V., Felfoldi, N., Telepo, K., Praly, J-P., Docsa, T., Gergely, P., Alexacou, J-M., Leonidas, D.D., Zographos, S.E., Oikonomakos, N.G., Somsak, L. Synthesis, kinetic and crystallographic evaluation of N-acyl-N'(b-D-glucopyranosyl)ureas, nanomolar glucose analogue inhibitors of glycogen phosphorylase, potential antidiabetic agents.
 

 

 

 

 
 


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