Institute of Chemical Biology - National Hellenic Research Foundation

Organic/Organometallic Chemistry & Catalysis
Dr Ioannis D. Kostas | Research Director, Group Leader

About Team Collaborations Funding Publications

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Main Research Directions / Ongoing Research Activities

Our investigations include the development of transition-metal (e.g. Ru, Rh, Pd, Pt) complexes with novel ligands and their evaluation as catalysts in reactions of enormous academic and industrial interest, such as hydroformylation, hydrogenation, coupling reactions (Heck, Suzuki).

More specifically, our research activities include:

(a) Catalysis by hybrid and hemilabile phosphorus ligands (e.g. phosphines, phosphine oxides, phosphinites, mixed phosphine-phosphinites) possessing additional potential donors such as oxygen, nitrogen, sulfur (e.g. I – IV).
(b) Catalysis in air by phosphane-free ligands such as thiosemicarbazones (e.g. V, VII) and chalcogen-containing Schiff bases. We are pioneers in the use of thiosemicarbazones as catalyst precursors for palladium-catalyzed coupling reactions (Heck, Suzuki), under aerobic conditions, and one of our Pd complexes is commercially available from MERCK (SIGMA-ALDRICH) (Product No.: 674125) and other companies.
(c) Asymmetric catalysis with new chiral amino diphosphite, phosphonite, phosphite-phosphoramidite and phosphine-phosphoramidite ligands, such as Me-AnilaPhos (VI) as a highly efficient ligand for the rhodium-catalyzed enantioselective olefin hydrogenation (100% conversion after 10 min at r.t. and 1 bar pressure, 98% ee).
(d) Catalysis by high energy techniques such as microwave irradiation. This technique was used to the Suzuki coupling in air, catalyzed by a palladium complex with a thiosemicarbazone ligand (VII), which was totally inactive under conventional heating.
(e) Aqueous catalysis offering environmental benefits and also the advantage of recycling and reusing the catalyst. We have published the first study concerning the evaluation of air-stable and water-soluble metalloporphyrins (VIII) in the Suzuki reaction and also the selective hydrogenation of unsaturated aldehydes in neat water or in an aqueous/organic biphasic system. The catalysts could be easily recycled and reused.

Selected Publications

I.D. Kostas*, B.R. Steele* Catalysts 2020, 10 (10), 1107, 1–40 “Thiosemicarbazone Complexes of Transition Metals as Catalysts for Cross-Coupling Reactions”.
https://doi.org/10.3390/catal10101107
P.-C. Ioannou, C. Arbez-Gindre, M. Zoumpanioti, C. P. Raptopoulou, V. Psycharis, I. D. Kostas*, P. Kyritsis* J. Organomet. Chem. 2019, 879, 40–46 “Catalytic reactivity of the complexes [Pd{(Ph₂P)₂N(^tBu)-P,P´}X₂], X = Cl, Br, I, in the Suzuki-Miyaura C−C coupling reaction: Probing effects of the halogeno ligand X^- and the ligand’s^tBu group”.
https://doi.org/10.1016/j.jorganchem.2018.10.006
I.K. Stamatopoulos, M. Kapsi, M. Roulia, G.C. Vougioukalakis, C.P. Raptopoulou, V. Psycharis, I.D. Kostas*, L. Kollár*, P. Kyritsis* Polyhedron 2018, 151, 292–298 “Structural features and catalytic reactivity of [Pd{(Ph₂P)₂N(CH₂)₃Si(OCH₃)₃-κP,P’}I₂] and related complexes in hydroalkoxycarbonylation and Suzuki-Miyaura C–C cross-coupling reactions”.
https://doi.org/10.1016/j.poly.2018.05.041
I.D. Kostas*, G. Antonopoulou, C. Potamitis, C.P. Raptopoulou, V. Psycharis J. Organomet. Chem. 2017, 828, 133-141 “Platinum Complexes with a methoxy-amino phosphine or a nitrogen-containing bis(phosphine) ligand. Synthesis, characterization and application to hydrogenation of trans-cinnamaldehyde”.
https://doi.org/10.1016/j.jorganchem.2016.11.036
I.D. Kostas*, A.-C. Tenchiu, C. Arbez-Gindre, V. Psycharis, C.P. Raptopoulou Catal. Commun. 2014, 51, 15-18 “Room-temperature Suzuki-Miyaura coupling of aryl bromides with phenylboronic acid catalyzed by a palladium complex with an inexpensive nitrogen-containing bis(phosphinite) ligand”.
https://doi.org/10.1016/j.catcom.2014.03.014
K.A. Vallianatou, D.J. Frank, G. Antonopoulou, S. Georgakopoulos, E. Siapi, M. Zervou, I.D. Kostas* Tetrahedron Lett. 2013, 54(5), 397-401 “Rhodium-catalyzed asymmetric olefin hydrogenation by easily accessible aniline- and pyridine-derived chiral phosphites”.
https://doi.org/10.1016/j.tetlet.2012.11.023
C. Stangel, G. Charalambidis, V. Varda, A.G. Coutsolelos,* I.D. Kostas* Eur. J. Inorg. Chem. 2011, (30), 4709-4716 “Aqueous–Organic Biphasic Hydrogenation of trans-Cinnamaldehyde Catalyzed by Rhodium and Ruthenium Phosphane-Free Porphyrin Complexes”.
https://doi.org/10.1002/ejic.201100668
I.D. Kostas* Curr. Org. Synth. 2008, 5(3), 227-249 “Recent Advances on P,N-Containing Ligands for Transition-Metal Homogeneous Catalysis”.
https://doi.org/10.2174/157017908785133447
I.D. Kostas*, A.G. Coutsolelos*, G. Charalambidis, A. Skondra Tetrahedron Lett. 2007, 48(38), 6688-6691 “The first use of porphyrins as catalysts in cross-coupling reactions: a water-soluble palladium complex with a porphyrin ligand as an efficient catalyst precursor or the Suzuki–Miyaura reaction in aqueous media under aerobic conditions”.
https://doi.org/10.1016/j.tetlet.2007.07.141
K.A. Vallianatou, I.D. Kostas*, J. Holz, A. Börner Tetrahedron Lett. 2006, 47(45), 7947-7950 “Me-AnilaPhos: A new chiral phosphine–phosphoramidite ligand for a highly efficient Rh-catalyzed asymmetric olefin hydrogenation”.
https://doi.org/10.1016/j.tetlet.2006.08.136
I.D. Kostas*, B.R. Steele*, A. Terzis, S.V. Amosova, A.V. Martynov, N.A. Makhaeva Eur. J. Inorg. Chem. 2006, (13), 2642-2646 “New Palladium Complexes with S- or Se-Containing Schiff-Base Ligands as Efficient Catalysts for the Suzuki-Miyaura Cross-Coupling Reaction of Aryl Bromides with Phenylboronic Acid under Aerobic Conditions”.
https://doi.org/10.1002/ejic.200600180
I.D. Kostas*, G.A. Heropoulos*, D. Kovala-Demertzi*, P.N. Yadav, J.P. Jasinski, M.A. Demertzis, F.J. Andreadaki, G. Vo-Thanh, A. Petit, A. Loupy Tetrahedron Lett. 2006, 47(26), 4403-4407 “Microwave-promoted Suzuki-Miyaura cross-coupling of aryl halides with phenylboronic acid under aerobic conditions catalyzed by a new palladium complex with a thiosemicarbazone ligand”.
https://doi.org/10.1016/j.tetlet.2006.04.088
I.D. Kostas*, F.J. Andreadaki, D. Kovala-Demertzi*, C. Prentjas, M.A. Demertzis Tetrahedron Lett. 2005, 46(12), 1967-1970 “Suzuki-Miyaura cross-coupling reaction of aryl bromides and chlorides with phenylboronic acid under aerobic conditions catalyzed by palladium complexes with thiosemicarbazone ligands”.
https://doi.org/10.1016/j.tetlet.2005.02.003
D. Kovala-Demertzi*, P.N. Yadav, M.A. Demertzis, J.P. Jasiski, F.J. Andreadaki, I.D. Kostas* Tetrahedron Lett. 2004, 45(14), 2923-2926 “First use of a palladium complex with a thiosemicarbazone ligand as catalyst precursor for the Heck reaction”.
https://doi.org/10.1016/j.tetlet.2004.02.062
I.D. Kostas* J. Organomet. Chem. 2001, 626(1-2), 221-226 “Synthesis of new rhodium complexes with a hemilabile nitrogen-containing bis(phosphinite) or bis(phosphine) ligand. Application to hydroformylation of styrene”.
https://doi.org/10.1016/S0022-328X(01)00701-X

Catalysis by metal nanoparticles

We have synthesized metal nanoparticles (NPs) such as thiosemicarbazone-stabilised Pd NPs and Pt NPs using 3,3´-thiodipropionic acid as a protective agent as efficient catalysts for the Suzuki reaction and the selective hydrogenation of trans-cinnamaldehyde, respectively. The nanocatalysts could be recovered and reused.

Selected Publications

Pournara, D. Kovala-Demertzi*, N. Kourkoumelis, S. Georgakopoulos, I.D. Kostas* Catal. Commun. 2014, 43, 57-60 “Platinum/3,3´-thiodipropionic acid nanoparticles as recyclable catalysts for the selective hydrogenation of trans-cinnamaldehyde”.
https://doi.org/10.1016/j.catcom.2013.09.008
D. Kovala-Demertzi*, N. Kourkoumelis*, K. Derlat, J. Michalak, F.J. Andreadaki, I.D. Kostas* Inorg. Chim. Acta 2008, 361(5), 1562-1565 “Thiosemicarbazone-derivatised palladium nanoparticles as efficient catalyst for the Suzuki-Miyaura cross-coupling of aryl bromides with phenylboronic acid”.
https://doi.org/10.1016/j.ica.2007.09.038

Biologically active compounds – Medicinal Chemistry

The investigation includes the development of synthetic methodologies and synthesis of series of bioactive molecules for specific biological targets. In particular:

(a) BRAFV600E inhibitors. We have synthesized over 20 compounds (final products) such as new benzothiazole and indole derivatives containing amide or sulfonamide side-chains, some of which display promising inhibition selectivity towards BRAFV600E with IC₅₀ down to 7.9 μM. Two of these compounds exhibit strong anti-tumor action in vivo, while leaving unaffected normal cells.

(b) Non-Steroidal Selective Glucocorticoid Receptor Agonists (SEGRA). We have designed and synthesized a series of modified imino-benzothiazole-thioacetamides, three of which, were shown to inhibit hydrocortisone-mediated transactivation probably by binding to GR and displacement of hydrocortisone. One of the compounds shows interesting results but simultaneously problems of toxicity and solubility, while another is found to have only an IC₅₀ quite comparable to the hit compound.

(c) Glycogen phosphorylase inhibitors. We synthesized a series of β-D-glucopyranosyl-modified thiosemicarbazones, which found to be inhibitors of glycogen phosphorylase, a target for the design of type 2 diabetes therapeutics.

Selected Publications

K.-M. Alexacou, A.-C. Tenchiu (Deleanu), E.D. Chrysina, M.-D. Charavgi, I.D. Kostas*, S.E. Zografos, N.G. Oikonomakos, D.D. Leonidas* Bioorg. Med. Chem. 2010, 18(22), 7911-7922 “The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors”.
https://doi.org/10.1016/j.bmc.2010.09.039
A.-C. Tenchiu (Deleanu), I.D. Kostas*, D. Kovala-Demertzi, A. Terzis Carbohydr. Res. 2009, 344(11), 1352-1364 “Synthesis and characterization of new aromatic aldehyde/ketone 4-(β-D-glucopyranosyl)thiosemicarbazones”.
https://doi.org/10.1016/j.carres.2009.05.010

Main Group organometallic chemistry

organometallic chemistry

Historically the group has been very active in the study and use of Main Group metal alkoxides and organometallic compounds. The preparation of organolithium compounds by reductive lithiation using aromatic radical anions has become known as the Screttas lithiation or the Screttas-Yus reaction. We have also shown that the use of metal alkoxide additives can radically alter the reactivity of organometallic reagents. We exploit these properties for the development of new synthetic methodologies and a particular instance is the discovery of a new and simple procedure for the synthesis of novel sterically hindered aromatic compounds.

Selected Publications

C.G. Screttas, B.R. Steele, M. Micha-Screttas, G.A. Heropoulos Organic Letters 2012, 14(22), 5680– 5683 “Aryllithiums with increasing steric crowding and lipophilicity prepared from chlorides in diethyl ether. the first directly prepared room-temperature-stable dilithioarenes”.
https://doi.org/10.1021/ol302672n

Education & Training

Coordinator of the training seminar “Contemporary Organic Chemistry and Applications” for high school teachers, Athens, May 1998.
Courses in “Transition-metal homogeneous catalysis. Applications to organic synthesis” within the EST Marie Curie “EURODESY” (2006-2010).
Active participation as lecturer/tutorial in the following Inter-institutional Programmes of Postgraduate Studies (joint Master's Degree):
1. “Bio-entrepreneurship” (2015-present), co-organized by the University of Thessaly / Department of Biochemistry and Biotechnology and the NHRF / Institute of Chemical Biology (http://www.bioepixirin.bio.uth.gr/en/). Topic of the courses provided by I.D. Kostas: “Dendrimers and Bioapplications”.
2. "Oncology: from Oncogenesis to Treatment" (2019-present), co-organized by the University of Crete / School of Medicine, and NHRF / Institute of Chemical Biology (http://www.med.uoc.gr/?q=metaptyxiaka/programmata/ogkologia). Topic of the courses provided by I.D. Kostas: “Drug Nanocarriers. Part A: Dendrimers”.
Training-through-research under the supervision for undergraduate, MSc, PhD students and Post-docs (25 in total).
Member of the organizing committee and/or chair in educational workshops:
1. Workshop “Supragene” (2008).
2. Workshop “Asymmetric Synthesis and Non-Conventional Advanced Synthetic Techniques for Fine Chemicals and Pharmaceuticals” (2010).
3. “Targeted Drug Discovery Workshop”, Athens, 10-14 October 2016.
Keynote speaker in the Workshop "Chemistry and Research Challenges" for undergraduate and graduate students, Athens 23-24/4/2013.

Science & Society

Organization of the educational event for the general public "Green Chemistry", Athens, 11 & 18 March 2014.
Active participation in “open days” for high school pupils including laboratory processes demonstration (interrupted in 2020 due to Covid19 pandemic).
Keynote speaker and head in educational chemistry experiments under specific cultural events for school pupils and for the general public, e.g.
- SCIENCE in SOCIETY, Athens, 12 December 2011
- "Chemistry, our life, our future", NHRF – 27/2/2011
- “Sunday Mornings”, NHRF – 20/11/2011
- "Science and Technology Festival 2012", NHRF, 13-16/12/2012
- “Green Chemistry, a Growing Environmental Need”, interview in Tech Talks Central, 27/6/2015
- Regular participation in “Researcher’s Night” events
- Regular participation in “Athens Science Festival” events
- People’s University, Athens 23 October 2018
- Nea Genia Ziridis, Cambridge International School, Athens 18 February 2020

Group Structure and Personnel

Members of the team from 2018 to present

Ioannis D. Kostas, PhD, Group Leader, Research Director
Barry R. Steele, PhD, Researcher Emeritus
Constantinos G. Screttas, PhD, Researcher Emeritus
Georgia Antonopoulou, PhD, Scientific Technical personnel

Post-doctoral Researchers
Dr. Alia-Cristina Tenchiu (Deleanu), 2018
Dr. Eleftherios Ferentinos, 2020-2021
Dr. Polydoros-Chrysovalantis Ioannou, 2020-2021

PhD Students
Polydoros-Chrysovalantis Ioannou, 2015-2018 (PhD/2018)
Yakinthi Batsi, 2017-present
Perikleia Diamantopoulou, 2022-present

MSc students
Katerina Nasaj, 2017-2018 (MSc/2019)
Electra Chomata, 2021-present

Undergraduate Students
Orfeas Marinakos, 2019

Collaborations

Former and/or current collaborations (outside NHRF) with Universities / Research Institutes

National
Prof. Dr. A. Coutsolelos, University of Crete
Prof. Dr. G. Kokotos, University of Athens
Prof. Dr. D. Kovala-Demertzi, University of Ioannina
Asoc. Prof. Dr. P. Kyritsis, University of Athens
Prof. Dr. D.D. Leonidas, University of Thessaly
Dr. A. Terzis, Dr. C. Raptopoulou, Dr. V. Psycharis, NCSR “Democritos”

International
Prof. Dr. S.V. Amosova, Favorsky Irkutsk Institute of Chemistry (Russia)
Prof. Dr. A. Börner, Leibniz-Institut für Katalyse an der Universität Rostock (Germany)
Prof. Dr. G.S. Hanan, Université de Montréal (Canada)
Prof. Dr. E. Hey-Hawkins, University of Leipzig (Germany)
Prof. Dr. L. Kollár, University of Pécs and Szentágothai Science Center (Hungary)
Prof. Dr. E. Monflier, Université d’ Artois, Lens (France)
Prof. Dr. A. Pfaltz, Universität Basel (Switzerland
Prof. Dr. M.T. Reetz/Director, Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr (Germany)
Prof. Dr. J. Vohlídal, Charles University, Prague (Czech Republic).

Funding

Funded programmes with I.D. Kostas as coordinator / scientist in charge

European programmes

Marie Curie Host Fellowships for the Transfer of Knowledge “Supramolecular chemistry and gene therapeutic potential of amine-substituted cyclodextrin end-functionalized triazine dendrimers based on melamine” (SUPRAGENE) (2006 – 2010, budget 331.4 K€ for our Institute).
Marie Curie Early Stage Training (EST) “A European Research Training Site for the Design and Synthesis of Novel Neuroprotective and Hypoglycaemic Agents through a Multi-disciplinary Approach” (EURODESY) (2006 – 2010, budget 984.1 K€ for our Institute, sub-coordinator since 2006 and coordinator after the initial coordinator “passed away”).

National programmes

Program funded by the Mobility Program of the Greek National Youth Foundation “Contemporary Organic Chemistry and Applications” (6-16/5/1998; budget: 20.5 K€), training seminar for high school teachers.
Greece – Germany bilateral cooperation “New materials: Novel chiral nitrogen-containing phosphorus ligands for rhodium-catalyzed enantioselective hydroformylation” (2002-2004; budget: 15.4 K€ for our Institute). Partners: National Hellenic Research Foundation (Dr. I.D. Kostas), Leibniz-Institut für Organische katalyse e.V. (Prof. Dr. A. Börner), Project House Catalysis of Degussa AG (Dr. Axel Monsees).
A competitive GSRT project for the commercial exploitation of research results “Commercialization of new systems for the applied homogeneous catalysis” (2003-2005; budget: 44 K€ for our Institute).
Greece – Canada bilateral cooperation “Polymetallic hemilabile dendritic nanocatalysts. Synthesis, characterization and applications” (2002-2005; budget: 59.9 K€ for our Institute). Partners: National Hellenic Research Foundation (Dr. I.D. Kostas), Université de Montréal, Departement de chimie (Prof. Dr. G.S. Hanan).
Support of Young Researchers – Call Β’, ESPA 2014-2020, “Aqueous Asymmetric Homogeneous Catalysis” (2020-2021, budget 50 K€).
National Scholarships Foundation (IKY), Fellowship for the PhD student Yakinthi Batsi supervised by I.D. Kostas, “New heterocyclic derivatives as potential inhibitors of BRAF^V600E” (2018-2021; budget: 29.4 K€).
Internal programme with a budget constituted by the residues matching funds of the EU programmes REGPOT “ARCADE”, TOK Marie Curie “SUPRAGENE”, and EST Marie Curie “EURODESY”, “Design and synthesis of functional compounds with catalytic and/or bioapplications (IDK)” (2019-present; budget: 31.2 K€).

Funded programmes with I.D. Kostas as member and/or scientist in charge in tasks of the project

European programmes

FP7-REGPOT-2009-1 “Advancement of Research Capability for the Development of New Functional Compounds” (ARCADE) (2010–2013, budget: 2,45 M€ for our Institute).
COST action CM0802: European Phosphorus Sciences Network (PhoSciNet) (2009 – 2013). member of the Management Committee (Greek representative).

National programmes

Greece-Russia bilateral cooperation “Design and synthesis of hemilabile ligands for homogeneous catalysis” (1999 – 2001, budget: 12.9 K€ for our Institute). Partners: National Hellenic Research Foundation, Favorsky Irkutsk Institute of Chemistry, Siberian Branch of Russian Academy of Sciences.
A competitive GSRT project for the commercial exploitation of research results “New high added-value products” (2002-2004; budget: 44 K€ for our Institute).
Greece-Russia bilateral cooperation “Novel catalysts for industrially important chemical processes” (2002 – 2004, budget: 12.3 K€ for our Institute). Partners: National Hellenic Research Foundation, Favorsky Irkutsk Institute of Chemistry, Siberian Branch of Russian Academy of Sciences.
Excellence in the Research Institutes supervised by the GSRT “Novel strategies against neurodegeneration” (2002–2005, budget: 200 K€ for our Institute).
ARCHIMEDES: research in Technological Educational Institutes “Study of the metabolism of Vitamin A in liver diseases” (2003 – 2006).
PYTHAGORAS: research in Universities “Development of the model structure – properties in bis(thiosubstituted) complexes. Synthesis and applications to transition-metal catalysis and photocatalysis” (2004 – 2006).
Programme for the Promotion of the Exchange and Scientific Cooperation between Greece and Germany, IKYDA “Catalytically active rhodium, palladium and zinc complexes with sterically demanding hemilabile P,N–ligands” (2005 – 2006). Partners: National Hellenic Research Foundation, University of Leipzig.
A competitive GSRT program EPAN – Action 4.5/4.5.1 “Design and synthesis of new bioactive molecules” (2005 – 2008, budget: 1.125 Μ€ for our Institute).
Excellence in the Research Institutes supervised by the GSRT, 2nd cycle “Design and synthesis of new bioactive and functional molecules” (2005 – 2008, budget: 97.2 K€ for our Institute).
HERAKLEITOS II, Greek Ministry of Education, Life Long Learning and Religious Affairs “Synthesis, characterization and study of the catalytic activity of complexes Μ(P,P)X₂, Μ(Ε,P)X₂ and Μ(Ε,Ε)X₂; Μ= Ni, Pd, Pt; E=O, S, Se; X=Cl, Br” (2010 – 2013).
Developmental proposals of research institutions – KRIPIS "Targeted therapeutic approaches against degenerative diseases, with emphasis on cancer and aging” (STHENOS) (2014 – 2016), budget: 1.5 Μ€ for our Institute.
Developmental proposals of research institutions – KRIPIS “STHENOS-b: Targeted therapeutic approaches against degenerative diseases with special focus on cancer and ageing-optimisation of the targeted bioactive molecules” (2017 – 2020), budget: 750 Κ€ for our Institute.
EPANEK 2014 – 2020 Strengthening Research and Innovation Infrastructure “OPENSCREEN-GR”, budget: 237,5 Κ€ for our Institute.

Theses

I.D. Kostas* “Metal alkoxide modified organolithium reagents. Synthesis and stabilization of substituted lithioxyalkylithiums including the aza-analogues, in tetrahydrofuran, in the presence of magnesium 2-ethoxyethoxide” (in Greek). PhD Thesis, National and Kapodistrian University of Athens, Athens 1991.
I.D. Kostas* “1,3-Dipolar cycloaddition of nitrile oxides to 2,6- dibenzylidenecycloexanone” (in Greek). Undergraduate Thesis, Aristotle University of Thessaloniki, Thessaloniki 1991.

Books

I.D. Kostas (Editor) "Transition Metal Catalyzed Cross-Coupling Reactions”. Printed Edition of the Special Issue Published in Catalysts, MDPI, Basel, First Edition 2021.
https://www.mdpi.com/books/pdfview/book/4714, https://doi.org/10.3390/books978-3-0365-2576-1
I.D. Kostas (Editor) "Suzuki–Miyaura Cross-Coupling Reaction and Potential Applications". Printed Edition of the Special Issue Published in Catalysts, MDPI, Basel, First Edition 2017.
https://doi.org/10.3390/books978-3-03842-557-1

Book Chapters

I.D. Kostas* “Recent Advances in P,N-Containing Ligands for Transition-Metal Homogeneous Catalysis”. In Advances in Organic Synthesis, Atta-ur-Rahman, FRS (Ed.), Bentham Science, 2013, Vol. 6, pp. 3-58. Invited book chapter. https://doi.org/10.2174/9781608050291113060003, https://ebooks.benthamscience.com/book/9781608050291/
I.D. Kostas* “Other P/N-Ligands”. In Phosphorus Ligands in Asymmetric Catalysis – Synthesis and Applications, A. Börner (Ed.), Wiley-VCH, Weinheim, 2008, vol. 2, part IV, chapter 1.2, pp. 596-632. Invited book chapter.
http://eu.wiley.com/WileyCDA/WileyTitle/productCd-3527317465.html
N.G. Oikonomakos*, M.N. Kosmopoulou, D.D. Leonidas, E.D. Chrysina, C. Tiraidis, N. Bischler, K.E. Tsitsanou, S.E. Zographos, I.D. Kostas, G. Eisenbrand “Indirubin and indigo analogues as potential inhibitors of glycogenolysis: structural basis of glycogen phosphorylase inhibition”. In Indirubin, the red shape of indigo, L. Meijer, N. Guyard, L.A. Skaltsounis, G. Eisenbrand (eds.). Editions “Life in Progress”, Roscoff, 2006, Chapter 18, 177-189.
I.D. Kostas* “Applied Homogeneous Catalysis”. In Contemporary Organic Chemistry and Applications (in Greek), National Hellenic Research Foundation, Institute of Organic and Pharmaceutical Chemistry, Athens 1998, pp. 27-48.

Guest Editor of Special Issues

CATALYSTS (Academic Editor: Ioannis D. Kostas), Special Issue "Transition Metal Catalyzed Cross-Coupling Reactions" 2020.
https://www.mdpi.com/journal/catalysts/special_issues/cross_coupl_react
CATALYSTS (Academic Editor: Ioannis D. Kostas), Special Issue "Suzuki–Miyaura Cross-Coupling Reaction and Potential Applications". Papers were published during 2016-2017.
https://www.mdpi.com/journal/catalysts/special_issues/suzuki_miyaura

Editorials

I.D. Kostas* Catalysts 2021, 11 (4), 473, 1–2“Editorial Catalysts: Special Issue on Transition Metal Catalyzed Cross-Coupling Reactions”.
https://doi.org/10.3390/catal11040473

Publications in refereed journals

I.D. Kostas*, B.R. Steele* Catalysts 2020, 10 (10), 1107,1–40 “Thiosemicarbazone Complexes of Transition Metals as Catalysts for Cross-Coupling Reactions”
https://doi.org/10.3390/catal10101107
P.-C. Ioannou, C. Arbez-Gindre, M. Zoumpanioti, C. P. Raptopoulou, V. Psycharis, I. D. Kostas*, P. Kyritsis* J. Organomet. Chem. 2019, 879, 40–46 “Catalytic reactivity of the complexes [Pd{(Ph₂P)₂N(^tBu)-P,P´}X₂], X = Cl, Br, I, in the Suzuki-Miyaura C−C coupling reaction: Probing effects of the halogeno ligand X^- and the ligand’s^tBu group”.
https://doi.org/10.1016/j.jorganchem.2018.10.006
I.K. Stamatopoulos, M. Kapsi, M. Roulia, G.C. Vougioukalakis, C.P. Raptopoulou, V. Psycharis, I.D. Kostas*, L. Kollár*, P. Kyritsis* Polyhedron 2018, 151, 292–298 “Structural features and catalytic reactivity of [Pd{(Ph₂P)₂N(CH₂)₃Si(OCH₃)₃-κP,P’}I₂] and related complexes in hydroalkoxycarbonylation and Suzuki-Miyaura C–C cross-coupling reactions”.
https://doi.org/10.1016/j.poly.2018.05.041
I. Stamatopoulos, M. Roulia, K.A. Vallianatou, C.P. Raptopoulou, V. Psycharis, M. Carravetta, C. Papachristodoulou, E. Hey-Hawkins, I.D. Kostas*, P. Kyritsis* ChemistrySelect 2017, 2 (36), 12051-12059 “Immobilization of [Pd{(Ph₂P)₂N(CH₂)₃Si(OCH₃)₃-κP,P'}X₂] (X=Cl, Br) onto Montmorillonite: Investigating their Performance as Homogeneous or Heterogenized Suzuki-Miyaura Catalysts”. https://doi.org/10.1002/slct.201702601
I.D. Kostas*, G. Antonopoulou, C. Potamitis, C.P. Raptopoulou, V. Psycharis J. Organomet. Chem. 2017, 828, 133-141 “Platinum Complexes with a methoxy-amino phosphine or a nitrogen-containing bis(phosphine) ligand. Synthesis, characterization and application to hydrogenation of trans-cinnamaldehyde”.
https://doi.org/10.1016/j.jorganchem.2016.11.036
A.-C. Tenchiu, I.-K. Ventouri, G. Ntasi, D. Palles, G. Kokotos, D. Kovala-Demertzi, I.D. Kostas* Inorg. Chim. Acta 2015, 435, 142-146 "Synthesis of a palladium complex with a β-D-glucopyranosyl-thiosemicarbazone and its application in the Suzuki-Miyaura coupling of aryl bromides with phenylboronic acid"
https://doi.org/10.1016/j.ica.2015.06.019
I.D. Kostas*, A.-C. Tenchiu, C. Arbez-Gindre, V. Psycharis, C.P. Raptopoulou Catal. Commun. 2014, 51, 15-18 “Room-temperature Suzuki-Miyaura coupling of aryl bromides with phenylboronic acid catalyzed by a palladium complex with an inexpensive nitrogen-containing bis(phosphinite) ligand”
https://doi.org/10.1016/j.catcom.2014.03.014
A. Pournara, D. Kovala-Demertzi^*, N. Kourkoumelis, S. Georgakopoulos, I.D. Kostas^* Catal. Commun. 2014, 43, 57-60 “Platinum/3,3´-thiodipropionic acid nanoparticles as recyclable catalysts for the selective hydrogenation of trans-cinnamaldehyde”.
https://doi.org/10.1016/j.catcom.2013.09.008
K.A. Vallianatou, D.J. Frank, G. Antonopoulou, S. Georgakopoulos, E. Siapi, M. Zervou, I.D. Kostas* Tetrahedron Lett. 2013, 54(5), 397-401 “Rhodium-catalyzed asymmetric olefin hydrogenation by easily accessible aniline- and pyridine-derived chiral phosphites”.
https://doi.org/10.1016/j.tetlet.2012.11.023
P. Pongrácz, I.D. Kostas, L. Kollár* J. Organomet. Chem. 2013, 723, 149-153 “Platinum complexes of P,N- and P,N,P-ligands and their application in the hydroformylation of styrene”.
https://doi.org/10.1016/j.jorganchem.2012.10.018
C. Stangel, G. Charalambidis, V. Varda, A.G. Coutsolelos,* I.D. Kostas* Eur. J. Inorg. Chem. 2011, (30), 4709-4716 “Aqueous–Organic Biphasic Hydrogenation of trans-Cinnamaldehyde Catalyzed by Rhodium and Ruthenium Phosphane-Free Porphyrin Complexes”.
https://doi.org/10.1002/ejic.201100668
K.-M. Alexacou, A.-C. Tenchiu (Deleanu), E.D. Chrysina, M.-D. Charavgi, I.D. Kostas*, S.E. Zografos, N.G. Oikonomakos, D.D. Leonidas* Bioorg. Med. Chem. 2010, 18(22), 7911-7922 “The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors”
https://doi.org/10.1016/j.bmc.2010.09.039
A.-C. Tenchiu (Deleanu), I.D. Kostas*, D. Kovala-Demertzi, A. Terzis Carbohydr. Res. 2009, 344(11), 1352-1364 “Synthesis and characterization of new aromatic aldehyde/ketone 4-(β-D-glucopyranosyl)thiosemicarbazones”
https://doi.org/10.1016/j.carres.2009.05.010
I.D. Kostas*, F.J. Andreadaki, E.A. Medlycott, G.S. Hanan, E. Monflier Tetrahedron Lett. 2009, 50(16), 1851-1854 “Synthesis of a halo-methylphenylene periphery-functionalized triazine-based dendritic molecule with a 3,3´-dimethyl-biphenyl linker using tris(halo-methylphenylene)triazines as building blocks”
https://doi.org/10.1016/j.tetlet.2009.02.011
I.D. Kostas* Curr. Org. Synth. 2008, 5(3), 227-249 “Recent Advances on P,N-Containing Ligands for Transition-Metal Homogeneous Catalysis”. Invited Article.
https://doi.org/10.2174/157017908785133447
D. Kovala-Demertzi*, N. Kourkoumelis*, K. Derlat, J. Michalak, F.J. Andreadaki, I.D. Kostas* Inorg. Chim. Acta 2008, 361(5), 1562-1565 “Thiosemicarbazone-derivatised palladium nanoparticles as efficient catalyst for the Suzuki-Miyaura cross-coupling of aryl bromides with phenylboronic acid”
https://doi.org/10.1016/j.ica.2007.09.038
I.D. Kostas*, K.A. Vallianatou, J. Holz, A. Börner* Tetrahedron Lett. 2008, 49(2), 331-334 “A new easily accessible chiral phosphite-phosphoramidite ligand based on 2-anilinoethanol and R-BINOL moieties for Rh-catalyzed asymmetric olefin hydrogenation”
https://doi.org/10.1016/j.tetlet.2007.11.049
I.D. Kostas*, A.G. Coutsolelos*, G. Charalambidis, A. Skondra Tetrahedron Lett. 2007, 48(38), 6688-6691 “The first use of porphyrins as catalysts in cross-coupling reactions: a water-soluble palladium complex with a porphyrin ligand as an efficient catalyst precursor or the Suzuki–Miyaura reaction in aqueous media under aerobic conditions”
https://doi.org/10.1016/j.tetlet.2007.07.141
K.A. Chatziapostolou, K.A. Vallianatou, A. Grigoropoulos, C.P. Raptopoulou, A. Terzis, I.D. Kostas*, P. Kyritsis*, G. Pneumatikakis J. Organomet. Chem. 2007, 692(19), 4129-4138 “Synthesis and characterization of new Rh^I complexes bearing CO, PPh₃ and chelating P,O- or Se,Se-ligands. Application to hydroformylation of styrene”
https://doi.org/10.1016/j.jorganchem.2007.06.032
K.A. Vallianatou, I.D. Kostas*, J. Holz, A. Börner Tetrahedron Lett. 2006, 47(45), 7947-7950 “Me-AnilaPhos: A new chiral phosphine–phosphoramidite ligand for a highly efficient Rh-catalyzed asymmetric olefin hydrogenation”
https://doi.org/10.1016/j.tetlet.2006.08.136
I.D. Kostas*, B.R. Steele*, A. Terzis, S.V. Amosova, A.V. Martynov, N.A. Makhaeva Eur. J. Inorg. Chem. 2006, (13), 2642-2646 “New Palladium Complexes with S- or Se-Containing Schiff-Base Ligands as Efficient Catalysts for the Suzuki-Miyaura Cross-Coupling Reaction of Aryl Bromides with Phenylboronic Acid under Aerobic Conditions”
https://doi.org/10.1002/ejic.200600180
I.D. Kostas*, G.A. Heropoulos*, D. Kovala-Demertzi*, P.N. Yadav, J.P. Jasinski, M.A. Demertzis, F.J. Andreadaki, G. Vo-Thanh, A. Petit, A. Loupy Tetrahedron Lett. 2006, 47(26), 4403-4407 “Microwave-promoted Suzuki-Miyaura cross-coupling of aryl halides with phenylboronic acid under aerobic conditions catalyzed by a new palladium complex with a thiosemicarbazone ligand”
https://doi.org/10.1016/j.tetlet.2006.04.088
E.I. Tolis, K.A. Vallianatou, F.J. Andreadaki, I.D. Kostas*Appl. Organomet. Chem. 2006, 20(5), 335-337 “A new rhodium complex with a nitrogen-containing bis(phosphine oxide) ligand as an efficient catalyst for the hydroformylation of styrene”
https://doi.org/10.1002/aoc.1057
N.V. Dubrovina*, V.I. Tararov, A. Monsees, A. Spannenberg, I.D. Kostas, A. Börner* Tetrahedron: Asymmetry 2005, 16(22), 3640-3649 “New chiral 1,3-diphosphine ligands for Rh-catalyzed enantioselective hydrogenation: a search for electronic effects”
https://doi.org/10.1016/j.tetasy.2005.08.048
S.V. Amosova*, N.A. Makhaeva, A.V. Martynov, V.A. Potapov, B.R. Steele, I.D. KostasSynthesis 2005, (10), 1641-1648 “Terminal organochalcogenoethyl- and -propylamines and their Schiff base derivatives”
https://doi.org/10.1055/s-2005-865310
N.G. Oikonomakos*, M.N. Kosmopoulou, E.D. Chrysina, D.D. Leonidas, I.D. Kostas, K.U. Wendt, T. Klabunde, E. Defossa Protein Sci. 2005, 14(7), 1760-1771 “Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs” https://doi.org/10.1110/ps.051432405
I.D. Kostas*, K.A. Vallianatou, J. Holz, A. Börner Appl. Organomet. Chem. 2005, 19(10), 1090-1095 “Rhodium complexes with a new chiral nitrogen-containing BINOL-based diphosphite or phosphonite ligand: synthesis and application to hydroformylation of styrene and/or hydrogenation of prochiral olefins”
https://doi.org/10.1002/aoc.977
I.D. Kostas*, F.J. Andreadaki, D. Kovala-Demertzi*, C. Prentjas, M.A. Demertzis Tetrahedron Lett. 2005, 46(12), 1967-1970 “Suzuki-Miyaura cross-coupling reaction of aryl bromides and chlorides with phenylboronic acid under aerobic conditions catalyzed by palladium complexes with thiosemicarbazone ligands”
https://doi.org/10.1016/j.tetlet.2005.02.003
I.D. Kostas*, K.A. Vallianatou, P. Kyritsis*, J. Zedník, J. Vohlídal* Inorg. Chim. Acta 2004, 357(10), 3084-3088 “Hydroformylation of alkenes catalyzed by new dinuclear aryloxide- and carboxylate-bridged rhodium complexes”. Invited paper in “Rhodium and Iridium Topical Issue”.
https://doi.org/10.1016/j.ica.2004.05.014
I.D. Kostas*, B.R. Steele, F.J. Andreadaki, V.A. Potapov Inorg. Chim. Acta 2004, 357(10), 2850-2854 “Rhodium complexes possessing S-phosphinite ligands with or without an amino group. Application to hydroformylation of styrene”. Invited paper in “Rhodium and Iridium Topical Issue”.
https://doi.org/10.1016/j.ica.2004.02.005
A.V. Martynov*, N.A. Makhaeva, V.A. Potapov, S.V. Amosova, B.R. Steele, I.D. Kostas Phosphorus Sulfur 2004, 179(7), 1373-1380 “Reduction of Terminal Organylchalcogeno Phosphonates as a Way to Prepare Primary Organylchalcogeno Phosphines”
https://doi.org/10.1080/10426500490463547
D. Kovala-Demertzi*, P.N. Yadav, M.A. Demertzis, J.P. Jasiski, F.J. Andreadaki, I.D. Kostas* Tetrahedron Lett. 2004, 45(14), 2923-2926 “First use of a palladium complex with a thiosemicarbazone ligand as catalyst precursor for the Heck reaction” https://doi.org/10.1016/j.tetlet.2004.02.062
I.D. Kostas* Inorg. Chim. Acta 2003, 355, 424-427 “Synthesis of new nitrogen-containing phosphinite and phosphine-phosphinite ligands. Application to rhodium-catalyzed hydroformylation of styrene”
https://doi.org/10.1016/S0020-1693(03)00252-4
I.D. Kostas*, B.R. Steele*, A. Terzis, S. V. Amosova Tetrahedron 2003, 59(19), 3467-3473 “A palladium complex with a new hemilabile amino- and sulfur-containing phosphinite ligand as an efficient catalyst for the Heck reaction of aryl bromides with styrene. The effect of the amino group”
https://doi.org/10.1016/S0040-4020(03)00474-5
M.T. Reetz*, I.D. Kostas, S.R. Waldvogel Inorg. Chem. Commun. 2002, 5(4), 252-254 “Synthesis of a gold(I) complex with a (thio)phosphine-modified β-cyclodextrin”
https://doi.org/10.1016/S1387-7003(02)00355-6
I.D. Kostas* J. Organomet. Chem. 2001, 634(1), 90-98 “Synthesis of a tetramethoxy and an amphiphilic tetrahydroxy hemilabile N,P,N-ligand. Coordination behavior towards rhodium(I) and application to hydroformylation of styrene or hydrogenation of trans-cinnamaldehyde” https://doi.org/10.1016/S0022-328X(01)01116-0
I.D. Kostas* J. Organomet. Chem. 2001, 626(1-2), 221-226 “Synthesis of new rhodium complexes with a hemilabile nitrogen-containing bis(phosphinite) or bis(phosphine) ligand. Application to hydroformylation of styrene”
https://doi.org/10.1016/S0022-328X(01)00701-X
C.S. Salteris, I.D. Kostas, M. Micha-Screttas, B.R. Steele, G.A. Heropoulos, C.G. Screttas*, A. Terzis J. Organomet. Chem. 1999, 590(1), 63-70 “Synthesis of lithium ω-(m- and p-lithiophenoxy)alkoxides modified with magnesium 2-ethoxyethoxide. Crystal structures of bis[4-(2-hydroxyethoxy)phenyl]mercury and bis[4-(3-hydroxypropoxy)phenyl]mercury”
https://doi.org/10.1016/S0022-328X(99)00425-8
I.D. Kostas* J. Chem. Res. (S) 1999, (10), 630-631 “Hydroaminomethylation of Styrene with Morpholine Catalysed by a Rhodium Complex with a Phosphino Amino Alcohol Ligand”
https://doi.org/10.1039/A904041B
C.S. Salteris, I.D. Kostas, M. Micha-Screttas, G.A. Heropoulos, C.G. Screttas*, A. Terzis Main Group Met. Chem. 1999, 22(7), 427-434 “ortho-Directed Lithiation of ω-Phenoxyalkanethiols and N,N-Dimethyl-ω-phenoxyalkylamines. Crystal Structure of Bis[o-[(2-dimethylamino)ethoxy]phenyl]-mercury”
https://doi.org/10.1515/MGMC.1999.22.7.427
C.S. Salteris, I.D. Kostas, M. Micha-Screttas, G.A. Heropoulos, C.G. Screttas*, A. Terzis J. Org. Chem. 1999, 64(15), 5589-5592 “Ortho-Directed Lithiation of ω-Phenoxy Alcohols”
https://doi.org/10.1021/jo990443p
I.D. Kostas*, C.G. Screttas* J. Organomet. Chem. 1999, 585(1), 1-6 “New rhodium complexes with P,N-ligands possessing a hydroxy or methoxy group. Synthesis, characterization and application to hydroformylation of styrene”
https://doi.org/10.1016/S0022-328X(99)00181-3
I.D. Kostas, O.S. Akkerman, F. Bickelhaupt*, N. Veldman, A.L. Spek J. Organomet. Chem. 1999, 572(1), 93-104 “Intraannular functionalization of the 1,3-phenylene-19-crown-6 system via bromine-lithium exchange”
https://doi.org/10.1016/S0022-328X(98)00884-5
I.D. Kostas, C.G. Screttas* Main Group Met. Chem. 1997, 20(12), 787-790 "Synthesis of Tetrahydrofuran-Stable ω-Lithioxy-azaalkyllithiums"
https://doi.org/10.1515/MGMC.1997.20.12.787
I.D. Kostas, C.G. Screttas*, C.P. Raptopoulou, A. Terzis Tetrahedron Lett. 1997, 38(50), 8761-8764 "A Remarkable Tendency of o-Lithio-N-(2-lithiooxyethyl)-N-methyl-aniline to Form Heterocyclic Derivatives by its Reaction with Dichlorodialkylsilanes or Silicon Tetrachloride. Synthesis of 2,5,1-Benzoxazasilepines and of the Silaspiro Analogue"
https://doi.org/10.1016/S0040-4039(97)10345-8
I.D. Kostas, C.G. Screttas* J. Org. Chem. 1997, 62(16), 5575-5577 "Synthesis and Applications of Tetrahydrofuran-Stable Substituted 3-(Lithioxyalkyl)- and 4-(Lithioxyalkyl)lithiums, Modified with Magnesium 2-Ethoxyethoxide"
https://doi.org/10.1021/jo9703010
I.D. Kostas, G-J.M. Gruter, O.S. Akkerman, F. Bickelhaupt*, H. Kooijman, W.J.J. Smeets, A.L. Spek Organometallics 1996, 15(21), 4450-4458 "Functionalization of 1,3-Phenylene-16-crown-5 via Direct Lithiation"
https://doi.org/10.1021/om960431j

Announcements in Conferences

Total number of abstracts: 92; in International and European Conferences: 55; in National Conferences: 37. Plenary lectures: 4; Oral presentations: 29; Posters: 59.